PMID: 38809Jan 1, 1978

Norepinephrine turnover under neuroleptic treatment of schizophrenic syndromes (author's transl)

Arzneimittel-Forschung
E EbenE Rüther

Abstract

In 45 psychotic in-patients with the paranoid-hallucinatory syndrome, the psychopathology, the extrapyramidal motor disturbances and 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) in CSF were investigated. A 15-day treatment with haloperidol induced significant increase of MHPG in CSF; after 10 days clozapine treatment MHPG was significantly reduced. 10 days later the normal values were reached again. The investigation of MHPG in CSF under treatment with neuroleptics showed no correlation between antipsychotic activity and the turnover of central norepinephrine.

Related Concepts

Lenticulostriate Disorders
Leponex
Haldol
Methoxyhydroxyphenylglycol, (-)-Isomer
Norepinephrine, (+, -)-Isomer
Schizophrenia
Antipsychotic Effect

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