PMID: 1208626Sep 1, 1975Paper

Norepinephrine uptake by hypothalamic tissue from the rat related to feeding

Pharmacology, Biochemistry, and Behavior
J Van der Gugten, J L Slangen

Abstract

Norepinephrine (NE) uptake by rat hypothalamus in vitro was studied in relation to food intake. Significant daily variations in NE uptake were observed in caudal hypothalamus from freely feeding rats. A maximal elevation occurred at the beginning of the night when food intake is also increasing to a maximum. NE uptake by caudal hypothalamus from relatively hungry rats previously adjusted to restricted feeding during the daytime was enhanced in afternoon and evening when compared with uptake by tissue from ad lib feeding animals. Determination of NE uptake by caudal hypothalamus from freely feeding individual rats and registration of individual meals taken by these rats revealed a relation between hypothalamic neuronal activity and the feeding pattern of the rat. A positive correlation was observed between NE uptake in vitro and feeding rate during a 2- to 4-hr interval. It also appeared that NE uptake by caudal hypothalamus is dependent on the time elapsed after the last meal. The data were evaluated in view of physiological studies concerning the onset of feeding and the hypothesis of hypothalamic adrenergic control of food intake.

References

Jul 12, 1974·Science·R J WurtmanJ D Fernstrom
Apr 1, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·E FriedmanS Gershon
Jul 1, 1973·Journal of Comparative and Physiological Psychology·J Le MagnenS Tallon
Nov 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P de Gasquet, E Pequignot
Aug 1, 1972·Journal of Neurochemistry·G CurzonP J Knott
Aug 25, 1972·Brain Research·F HéryJ Glowinski
Feb 10, 1968·Nature·J Manshardt, R J Wurtman
Sep 20, 1969·Nature·R B MontgomeryA G Bolt

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Citations

Sep 1, 1977·Pharmacology, Biochemistry, and Behavior·J van der Gugten, J L Slangen
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·E C de Rooy, D V Coscina
Jan 1, 1987·Progress in Neurobiology·A Wirz-Justice
Jul 1, 1982·Brain Research Bulletin·O Bosler, A Calas
Oct 28, 1977·Brain Research·J van der GugtenJ L Slangen
Jul 1, 1987·Brain Research·L L Bernardis, L L Bellinger

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