Norepinephrine uptake is enhanced in discrete telencephalic and diencephalic areas and nuclei in prehepatic portal hypertensive rats

Brain Research Bulletin
Abraham LembergB E Fernández

Abstract

Several evidences support the hypothesis that central catecholamines may play a significant role in the production and/or maintenance of different alterations that characterize portal hypertension. The aim of the present work was to study the possible modifications in norepinephrine (NE) metabolism in several telencephalic and diencephalic areas rich in NE in experimental prehepatic portal hypertension. NE uptake was studied as an index of NE metabolism. The experiments were carried out in vitro in encephalic areas and nuclei, obtained according to the punch-out technique. Results indicated that portal hypertensive rats showed an enhancement of NE uptake in olfactory bulb (OB), preoptic area (PA), and supraoptic, periventricular, paraventricular, and arcuate nuclei (SON, PeVN, PaVN, and AN, respectively) compared to sham-operated rats. However, no modifications on NE uptake was observed in the median eminence (ME). Present results suggest that the changes observed in central NE uptake may be related to the development and/or maintenance of the portal hypertensive state.

References

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Citations

Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daisheng SongSamuel S Lee
May 26, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Ahmed F AhmedShimaa M Elshazly
Jul 12, 2005·Neurochemistry International·Silvia Lores-ArnaizAbraham Lemberg
Apr 11, 2012·World Journal of Hepatology·Juan Carlos PerazzoSalvador Romay

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