Norine: A powerful resource for novel nonribosomal peptide discovery

Synthetic and Systems Biotechnology
Maude PupinValérie Leclère

Abstract

Since its first release in 2008, Norine remains the unique resource completely devoted to nonribosomal peptides (NRPs). They are very attractive microbial secondary metabolites, displaying a remarkable diversity of structure and functions. Norine (http://bioinfo.lifl.fr/NRP) includes a database now containing more than 1160 annotated peptides and user-friendly interfaces enabling the querying of the database, through the annotations or the structure of the peptides. Dedicated tools are associated for structural comparison of the compounds and prediction of their biological activities. In this paper, we start by describing the knowledgebase and the dedicated tools. We then present some user cases to show how useful Norine is for the discovery of novel nonribosomal peptides.

Citations

Jul 2, 2019·Natural Product Reports·Mohammad AlanjaryMarnix H Medema
May 27, 2017·Environmental Science and Pollution Research International·Qassim EsmaeelValérie Leclère
Mar 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Johannes ArpPierre Stallforth
Oct 16, 2016·Bioprocess and Biosystems Engineering·Philippe JacquesRénato Froidevaux
Nov 1, 2020·World Journal of Microbiology & Biotechnology·Pratika SinghAmrita Srivastava
Sep 14, 2019·Biotechnology Advances·Antoine VassauxValérie Leclère
Dec 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Verónica RojasFanny Guzmán
Jul 24, 2021·Journal of Applied Microbiology·Maliheh BakhtiyarizadehJahan B Ghasemi
Oct 27, 2021·ACS Chemical Biology·Matthew A HostetlerElizabeth I Parkinson

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Software Mentioned

antiSMASH
Norine
smiles2monomers
s2m
NaPDos
MyNorine
Florine

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