Normal Amplitude of Electroretinography and Visual Evoked Potential Responses in AβPP/PS1 Mice

Journal of Alzheimer's Disease : JAD
Henri LeinonenHeikki Tanila

Abstract

Alzheimer's disease has been shown to affect vision in human patients and animal models. This may pose the risk of bias in behavior studies and therefore requires comprehensive investigation. We recorded electroretinography (ERG) under isoflurane anesthesia and visual evoked potentials (VEP) in awake amyloid expressing AβPPswe/PS1dE9 (AβPP/PS1) and wild-type littermate mice at a symptomatic age. The VEPs in response to patterned stimuli were normal in AβPP/PS1 mice. They also showed normal ERG amplitude but slightly shortened ERG latency in dark-adapted conditions. Our results indicate subtle changes in visual processing in aged male AβPP/PS1 mice specifically at a retinal level.

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Citations

Jul 29, 2016·Human Molecular Genetics·Henri LeinonenPeppi Koivunen
Feb 27, 2018·Journal of Alzheimer's Disease : JAD·Jillian L KingRichard E Brown
May 11, 2017·Scientific Reports·Henri LeinonenKatja M Kanninen
Feb 6, 2021·Frontiers in Aging Neuroscience·Elena Salobrar-GarcíaJosé M Ramírez
Aug 6, 2021·Neuroscience Insights·Vladan BajicGeorge Perry
Apr 16, 2021·Current Alzheimer Research·Li GuoM Francesca Cordeiro

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