PMID: 2422051Jan 1, 1986Paper

Normal and abnormal aspects of proteinuria. Part I: Mechanisms, characteristics and analyses of urinary protein. Part II: Clinical considerations

Experimental Pathology
E P Lillehoj, M D Poulik

Abstract

Part I highlights the mechanisms of glomerular filtration and tubular reabsorption of plasma proteins, selected characteristics of urinary proteins based upon electrophoretic properties and recent advances in clinical laboratory analysis of proteinuria. Both structural characteristic of the glomerular capillary wall and molecular properties of plasma proteins are important determinants of glomerular filtration. Proteins filtered by the glomerulus subsequently appear in urine only after escaping the efficient mechanisms of tubular reabsorption. Albumin is one such protein and constitutes the major protein in normal urine although trace amounts of alpha, beta, and gamma globulins are also detectable. Several techniques of protein analysis have thus been developed to specifically measure albumin as well as other plasma proteins. Other methods have been adapted to measure total urinary protein content enabling the clinician to readily monitor renal function in health and disease. The second part of this review will consider conditions associated with proteinuria in both asymptomatic individuals and patients with renal disease. Asymptomatic proteinuria encompasses states of excess protein excretion during conditions of orthostasis, ...Continue Reading

References

Apr 23, 1977·Lancet·D J Fletcher
Sep 24, 1977·Lancet·J M BarragryR D Cohen
Aug 18, 1975·Biochemical and Biophysical Research Communications·B EkströmI Berggård
Aug 26, 1978·Lancet·G Lindstedt, G Westberg
Jan 1, 1978·International Urology and Nephrology·I TishkovP Shipkova
Jan 1, 1979·Annual Review of Medicine·C L Hall, J Hardwicke
Jan 1, 1978·Acta Haematologica·G VirellaJ Gonzalez
May 1, 1976·Journal of Clinical Pathology·W LawlerN P Mallick
Feb 27, 1976·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·W H BoeskenG Schneider
Feb 1, 1977·Australian and New Zealand Journal of Medicine·R Woodruff, B Sweet
Jan 1, 1977·Nephron·K SethiV E Pollak
Jul 1, 1977·Transplantation·R J RubinJ T Harrington
Feb 1, 1978·The American Journal of Medicine·R D GilesW K Bolton
Jan 1, 1977·Scandinavian Journal of Urology and Nephrology·L Hemmingsen, P Skaarup
Feb 24, 1979·British Medical Journal
May 12, 1979·British Medical Journal
Jan 1, 1977·International Urology and Nephrology·J Buchanec, K Javorka
Jan 1, 1978·The Journal of Clinical Investigation·M P BohrerB M Brenner
Feb 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·H HaugenA Meberg
Apr 13, 1978·The New England Journal of Medicine·B M BrennerH D Humes
May 1, 1978·Annals of Internal Medicine·M J RezaR A Kark
Jun 1, 1978·The British Journal of Dermatology·K B CookeR C Staughton
Sep 1, 1978·American Family Physician·J Lemann
Jul 1, 1978·British Journal of Diseases of the Chest·A Pines
Dec 1, 1978·The Journal of Infectious Diseases·R MarierV T Andriole
Dec 1, 1976·The Journal of Surgical Research·M MuraiH M Lee
Jan 8, 1976·The New England Journal of Medicine·N SmithlineJ J Cohen
Jul 1, 1977·The Journal of Pediatrics·G Lindstedt
Jan 1, 1975·Archives of Internal Medicine·Z JancelewiczW Pruzanski
Feb 1, 1975·British Medical Journal·L S IbelsJ H Stewart
Nov 3, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·N BorgP Skaarup
Dec 11, 1975·Toxicology and Applied Pharmacology·P H GitlitzP J Goldblatt
Jan 1, 1990·Nephron·R H WHITEA Green
Jan 1, 1987·Advances in Nephrology From the Necker Hospital·C PonticelliE Imbasciati
Feb 20, 1971·Lancet·B K SharmaG Dunea
Aug 21, 1971·Lancet·J A CotterillL Bulusu
Dec 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·P E EvrinI Berggård
Jul 30, 1966·Lancet·J S CAMERON, G Blandford
Mar 1, 1968·The Journal of Experimental Medicine·P H Lambert, F J Dixon
Aug 1, 1974·European Journal of Clinical Investigation·J C MulliJ Fabre
May 5, 1973·British Medical Journal·J M WellwoodA E Thompson
Aug 1, 1973·Transplantation·R H SchwartzR B Freeman
Mar 16, 1974·British Medical Journal·O M PetruccoM W Weldon
Jan 1, 1974·Nephron·J E Bourdeau, F A Carone
Jan 1, 1974·Nephron·W Strober, T A Waldmann
Feb 1, 1973·Polskie Archiwum Medycyny Wewnętrznej·L Gradowska
Jan 1, 1973·Guy's Hospital Reports·R J Robinson
May 17, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·C G BengK S Lau
Jan 1, 1972·Internationale Zeitschrift für angewandte Physiologie, einschliesslich Arbeitsphysiologie·B TodorovićV Pavlović-Kentera
Sep 9, 1972·British Medical Journal·R R HallA Munro Neville
Nov 1, 1969·Annals of Internal Medicine·R R Robinson
Jan 1, 1970·The Journal of Clinical Investigation·M A CortneyD D Weiss
Jan 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·R G PriceW R Cattell
Apr 1, 1970·Archives of Disease in Childhood·M I MarksK N Drummond
Jun 27, 1970·British Medical Journal·R Wilkinson, D W Eccleston
Dec 1, 1970·The Journal of Experimental Medicine·M A VenkatachalamR S Cotran
May 1, 1968·The American Journal of Medicine·T U BiberM C MacDowell
Jan 1, 1967·Journal of Clinical Pathology·J F Harrison, J D Blainey
Jan 1, 1982·International Archives of Allergy and Applied Immunology·D LeeJ M Dewdney
Nov 24, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·A BernardR R Lauwerys
Feb 1, 1983·Annals of Internal Medicine·J G Abuelo
Mar 1, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·J Lubega
May 1, 1980·Transplantation·K R McLeishR S Shapiro
May 1, 1982·Kidney International·J P Pennell, T L Meinking
Aug 1, 1981·British Journal of Urology·L HemmingsenH Wolf
Apr 1, 1954·The Journal of Clinical Investigation·F P CHINARDA HILLER
Dec 1, 1964·The Journal of Clinical Investigation·G R JOACHIME L BECKER
Feb 27, 1965·Lancet·J S CAMERON, R H WHITE
Aug 1, 1951·The Journal of Clinical Investigation·D A RIGAS, C G HELLER
Jan 1, 1952·The Journal of Experimental Medicine·I TAMM, F L HORSFALL

Citations

Sep 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G C Hard
Feb 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D S Gardiner, G B Lindop
Oct 1, 1990·American Journal of Respiratory Cell and Molecular Biology·A E Chung, M E Durkin
Feb 3, 2007·American Journal of Respiratory Cell and Molecular Biology·Fabian BlankPeter Gehr
Dec 17, 2009·Archives of Environmental & Occupational Health·Maria L Limson ZamoraKevin Capello
Nov 1, 1992·American Journal of Obstetrics and Gynecology·R W Stettler, F G Cunningham
Jan 1, 1989·Connective Tissue Research·P V TresconyL B Deloria
Mar 1, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Min LiMaria Pia Rastaldi
Aug 6, 2008·Expert Opinion on Drug Metabolism & Toxicology·Barbara Rothen-RutishauserPeter Gehr
Jan 1, 1997·Critical Reviews in Biochemistry and Molecular Biology·J T PriceE C Kohn
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·M KedingerK Haffen
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·U Hahn
Nov 10, 1992·Biochemistry·J Engel
May 2, 1988·European Journal of Biochemistry·L HartlR Deutzmann
Jan 1, 1990·Annals of the New York Academy of Sciences·K TryggvasonD J Prockop
Nov 23, 2005·Journal of Clinical Laboratory Analysis·Kayo YokomizoKiyoko Shiba
Feb 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E G Bade, S Feindler
Jan 26, 1999·Annals of the New York Academy of Sciences·R FleischmajerY Yamada
Jul 1, 1987·European Journal of Biochemistry·M PaulssonJ Engel
Dec 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·P Thorgaard AndersenJ Sørensen
Sep 15, 1989·International Journal of Cancer. Journal International Du Cancer·C ClavelP Birembaut
Aug 15, 1993·European Journal of Biochemistry·C GottschlingI Oberbäumer
Jun 1, 1990·Journal of Molecular Evolution·G ButticèM Kurkinen
Nov 5, 1997·Annals of the New York Academy of Sciences·C ZarowL S Perlmutter
Nov 1, 1989·The Histochemical Journal·F T BosmanM Havenith
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C BrummerH M Rabes
Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Simon-Philippe LebelMoise Bendayan
Mar 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Qi YanE Helene Sage
Aug 1, 1994·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·S M Hall, K Enver
Jul 4, 2001·Journal of Clinical Laboratory Analysis·G KoliakosI Sotiriou
Sep 1, 1999·Histopathology·L E De Las Casas, J L Finley
Nov 1, 1994·The Histochemical Journal·F QuondamatteoR Herken
May 1, 1992·The Anatomical Record·V Leardkamolkarn, D R Abrahamson
Aug 1, 1989·The American Journal of Anatomy·C P Leblond, S Inoue
Jan 4, 1998·Microscopy Research and Technique·P S Amenta, D Harrison
Nov 1, 1990·Molecular Reproduction and Development·H M KangW K Cho
Apr 1, 1990·The Anatomical Record·E A NunezR F Payette
Jun 1, 1994·Microscopy Research and Technique·H J Merker
Jun 1, 1994·Microscopy Research and Technique·T H van Kuppevelt, J H Veerkamp
Jan 1, 1994·Journal of Cellular Physiology·D J DonaldsonA E Chung
Aug 1, 1990·Journal of Cellular Physiology·J LaterraG W Goldstein
Feb 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Timpl, J C Brown
Nov 8, 2014·Luminescence : the Journal of Biological and Chemical Luminescence·Tayyebeh MadrakianAbbas Afkhami
Apr 1, 1990·Cell and Tissue Research·D Daga GordiniG M Bressan
Jan 1, 1996·Molecular Biology Reports·J Uitto, L Pulkkinen
Jul 1, 1992·Experimental Dermatology·J UittoA M Christiano
Dec 31, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T KainulainenT Salo
Jan 1, 1990·Annals of the New York Academy of Sciences·R PollnerK Kühn
Jan 1, 1990·Annals of the New York Academy of Sciences·P D Yurchenco
Apr 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M E PenfoldA L Cunningham
Apr 1, 1989·European Journal of Biochemistry·R Timpl
Sep 1, 1988·British Journal of Haematology·M Y Gordon
Jun 1, 1995·European Journal of Clinical Investigation·C WenischW Graninger
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P RossmannV Starý
Dec 1, 1994·Neuropathology and Applied Neurobiology·M K Enver, S M Hall
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·A Martinez-Hernandez, P S Amenta
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·A Skalova, I Leivo
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·I Damjanov
Jan 7, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Vijay G PeddareddigariRaymond N Dubois
May 15, 1993·Experientia·R Timpl
Jan 1, 1994·International Journal of Clinical & Laboratory Research·L ParnettiU Senin
Jan 1, 1992·Anatomy and Embryology·A Maier
Feb 27, 2007·Journal of Materials Science. Materials in Medicine·D GuarnieriP A Netti
Sep 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C E KashtanA J Fish
Jan 1, 1993·Journal of Biomaterials Science. Polymer Edition·R F ValentiniP Aebischer
Sep 30, 2008·Blood Pressure·Tetsuya FujimotoAkikazu Nomura
Jul 30, 2002·The Journal of Biological Chemistry·Jennifer L SmedbergXiang-Xi Xu
Jan 1, 1991·Critical Reviews in Toxicology·A Bernard, R R Lauwerys
Nov 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M KitaokaH Yoshioka
Feb 11, 1998·Transplantation·M A MaggardD K Imagawa
Aug 19, 1993·International Journal of Cancer. Journal International Du Cancer·J M LiebmanH K Kleinman
Aug 19, 1999·Australian Dental Journal·D F WilsonO W Wiebkin
Jun 9, 2011·The Journal of Clinical Hypertension·Louis KuritzkyPeter Van Buren
May 1, 1992·Journal of Morphology·Ruth Ann DewelBrenda G Roush
Jan 29, 2000·The American Journal of Clinical Nutrition·V SapinV Azaïs-Braesco
Jan 21, 1993·International Journal of Cancer. Journal International Du Cancer·V I GuelsteinA V Ljubimov
Jan 1, 1987·Progress in Biophysics and Molecular Biology·R Jaenicke
Dec 26, 2001·Chemical Reviews·S Liu, D S Edwards
Jul 29, 1988·Journal of Chromatography·M H Weber
Sep 13, 1991·Journal of Chromatography·A Bianchi-BosisioP G Righetti

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