Normal and clonal B lineage cells can be distinguished by their differential expression of B cell antigens and adhesion molecules in peripheral blood from multiple myeloma (MM) patients--diagnostic and clinical implications

Clinical and Experimental Immunology
R LuqueE Roldán

Abstract

Human MM is a haematologic disorder characterized by the accumulation of malignant plasma cells (PC), primarily in the bone marrow (BM). Although these cells characteristically home to the BM, in recent years several groups have detected the presence of related malignant B cells in the peripheral blood (PB) which could be implicated in the progression and spread of the disease. However, the proportion and origin of these clonotypic circulating B cells is still controversial. In this study, using a triple-staining flow cytometric procedure and a whole blood lysis method, PB B lineage cells could be divided into two populations according to their distinct repertoires of cell adhesion molecules and B cell antigens in untreated MM patients. The results show that: (i) the percentage and the absolute number of PB CD19+ B cells were decreased in MM patients compared with controls; (ii) the quantity and percentage of B cell antigens (CD20, CD22, CD24, DR, CD138) and adhesion molecules (beta1- and beta2-integrins, CD44, CD54, CD56, CD61 and CD62L) expressed by these PB CD19+ cells of MM patients and healthy subjects were similar and all of them were virtually polyclonal cells; (iii) a very minor circulating CD19-CD38++CD45-/dim subset w...Continue Reading

References

Aug 2, 1990·Nature·T A Springer
Mar 1, 1989·British Journal of Haematology·G ClofentR Bataille
Apr 1, 1988·European Journal of Haematology·M BoccadoroA Pileri
Jan 1, 1994·Acta Haematologica·A Tienhaara, T T Pelliniemi
Jan 1, 1995·The Journal of Clinical Investigation·R G HooverB Barlogie
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·T PapayannopoulouN S Wolf
Feb 1, 1993·The Journal of Clinical Investigation·M P Bevilacqua, R M Nelson
Jan 1, 1995·Current Topics in Microbiology and Immunology·T E WitzigP R Greipp
Jan 1, 1994·Cytometry·E Krömer, F Grossmüller
Jun 23, 1997·Journal of Immunological Methods·R X SunB Klein
Mar 21, 1998·British Journal of Haematology·N E KayM M Oken

❮ Previous
Next ❯

Citations

Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anna CorcioneVito Pistoia
Jun 11, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jingying ZhangBaiqin Qian
Jan 8, 2000·Hematology/oncology Clinics of North America·T E Witzig
Jan 13, 2015·Clinical Lymphoma, Myeloma & Leukemia·Pavla VšianskáRoman Hájek
Nov 21, 2007·Journal of Immunological Methods·Heather A Minges Wols, Pamela L Witte
Jan 1, 2016·Journal of Circulating Biomarkers·Liangxuan ZhangShidong Jia
Apr 1, 2005·Brain : a Journal of Neurology·Sabine CepokBernhard Hemmer
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M OdendahlT Dörner

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.