Normal and PPP-affected palmoplantar sweat gland express neuroendocrine markers chromogranins and synaptophysin differently

Archives of Dermatological Research
E HagforsenM Stridsberg

Abstract

Earlier findings indicate the acrosyringium as the target for the inflammation in the chronic and intensely inflammatory skin disease palmoplantar pustulosis (PPP). The sweat gland apparatus seems to be an immune-competent structure that probably contributes to the defence of the skin. Furthermore, the sweat gland and duct may be a hitherto unrecognized neuroendocrine organ because it expresses cholineacetyl-transferase and acetylcholinesterase, nicotinic receptors, beta-adrenergic and angiotensin receptors. The aim of this study was to obtain further information about neuroendocrine properties of the sweat gland apparatus by examining the expression of common neuroendocrine markers synaptophysin and chromogranins A and B in healthy palmar skin and in PPP skin. Synaptophysin and chromogranins were expressed in the sweat glands and ducts with some variation in the pattern and intensity of the expression. In PPP skin the expression differed, being higher and lower, depending on the part of the sweat duct. Chromogranins were further expressed in the epidermis, endothelium and inflammatory cells, but its intensity was weaker in epidermis than in the sweat gland apparatus. In most cases, chromogranins in epidermis in involved PPP we...Continue Reading

References

Nov 1, 1991·The British Journal of Dermatology·J M McGregorD M MacDonald
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·E GalindoD Aunis
Nov 1, 1989·The Journal of Investigative Dermatology·W HartschuhU Egner
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B WiedenmannV E Gould
Oct 4, 1985·Science·R H Angeletti, W F Hickey
May 15, 1998·The British Journal of Dermatology·M O ErikssonG Michaëlsson
Aug 10, 2000·Archives of Dermatological Research·E HagforsenG Michaëlsson
Mar 22, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G M Portela-Gomes, M Stridsberg
Jun 26, 2001·The British Journal of Dermatology·H Takeda, S Kondo
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A SlominskiE T Wei
Nov 6, 2001·Nature Immunology·B SchittekC Garbe
Feb 21, 2002·Regulatory Peptides·Christian M KählerChristian J Wiedermann
Jul 23, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Guida Maria Portela-Gomes, Mats Stridsberg
Nov 6, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Guida Maria Portela-Gomes, Mats Stridsberg
Nov 26, 2002·The Journal of Investigative Dermatology·Masamoto MurakamiRichard L Gallo
Mar 21, 2003·The New England Journal of Medicine·Laurent TaupenotDaniel T O'Connor
Feb 3, 2005·Biological Reviews of the Cambridge Philosophical Society·Karen B Helle
Aug 17, 2005·Current Protein & Peptide Science·Reiner Fischer-ColbrieAlois Saria
May 25, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Andrzej SlominskiDesmond J Tobin
Oct 4, 2006·Physiological Reviews·Dirk RoostermanMartin Steinhoff
Jan 11, 2008·The Journal of Investigative Dermatology·Katherine A RadekRichard L Gallo

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Citations

Oct 17, 2013·The Journal of Dermatology·Toshiyuki Yamamoto
Feb 1, 2011·The British Journal of Dermatology·U Mrowietz, P C M van de Kerkhof
Jan 12, 2019·Clinical Drug Investigation·Toshiyuki Yamamoto
Jun 25, 2020·Scientific Reports·Fatma El-Zahraa A MustafaDoaa M Mokhtar
Sep 5, 2020·Clinical, Cosmetic and Investigational Dermatology·Egídio FreitasTiago Torres
Mar 3, 2021·The Journal of Dermatology·Toshiyuki Yamamoto
Jul 1, 2021·Clinical Pharmacology : Advances and Applications·Toshiyuki Yamamoto

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