PMID: 9169856May 15, 1997Paper

Normal and reactive NG2+ glial cells are distinct from resting and activated microglia

Journal of Neuroscience Research
Akiko NishiyamaV K Tuohy

Abstract

We have previously used antibodies to the NG2 proteoglycan and the alpha receptor for platelet-derived growth factor (PDGF alpha receptor) to identify oligodendroglial progenitor cells in vivo and in vitro. It has recently become evident that the GD3 antigen, which has been widely used as a marker for oligodendrocyte progenitor cells, is also expressed by microglial cells. In this study we have examined the relationship between the NG2+/PDGF alpha receptor+ glial progenitor cells and microglial cells in normal developing and mature rat brain and in inflammatory lesions in mice with experimental autoimmune encephalomyelitis (EAE). Double-labeling of sections from normal rat brain using anti-NG2 antibodies and lectin from Griffonia simplicifolia (GSA I-B4) or monoclonal antibody 4H1 indicated that there is no overlap between NG2+ glial progenitor cells and microglia in the parenchyma of the central nervous system. In EAE lesions, both NG2+ cells and microglia, identified by antibodies to F4/80 and CD45, displayed reactive changes characterized by increased cell number and staining intensity and shortening and thickening of cell processes. Both cell types were found surrounding perivascular infiltrates of lymphocytes. Double-label...Continue Reading

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Citations

Mar 17, 2004·Biological Psychiatry·Malin WennströmAnders Tingström
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·S C ZhangI D Duncan
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y ShoshanS M Staugaitis
Feb 9, 2002·Journal of Anatomy·Diane R GoddardArthur M Butt
Apr 11, 2009·Brain : a Journal of Neurology·Alessia MelaniFelicita Pedata
Nov 22, 2007·Neoplasia : an International Journal for Oncology Research·Per Ø SakariassenMartha Chekenya
Dec 5, 2006·Neuroscience·L Vitellaro-ZuccarelloS De Biasi
Apr 9, 2008·Annals of Neurology·Kristen N SegoviaStephen A Back
Dec 6, 2008·The Journal of Comparative Neurology·Mila KomitovaAkiko Nishiyama
May 20, 2011·Journal of Anatomy·Nicole FröhlichMaria Kukley
May 30, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Helene L ClausMichael Schroeter
Apr 13, 2005·Neuroscience Letters·Jin NakaharaSadakazu Aiso
Dec 8, 2007·Trends in Neurosciences·Larry S Sherman, Stephen A Back
Nov 21, 2013·Acta Neuropathologica Communications·Henrietta M NielsenMalin Wennström
Nov 20, 2003·Biological Psychiatry·Malin WennströmAnders Tingström
Jun 12, 2002·Molecular and Cellular Neurosciences·Zhi Jiang ChenJoel M Levine
Jun 7, 2014·Frontiers in Neuroscience·Enrica Boda, Annalisa Buffo
Jul 16, 2014·Frontiers in Neuroscience·Akiko NishiyamaXiaoqin Zhu
Jun 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hiroaki MatsumotoJunya Tanaka
Jan 19, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Akiko Nishiyama

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