Normal-appearing cerebral white matter in healthy adults: mean change over 2 years and individual differences in change

Neurobiology of Aging
Andrew R Bender, Naftali Raz

Abstract

Diffusion tensor imaging studies show age-related differences in cerebral white matter (WM). However, few have studied WM changes over time, and none evaluated individual differences in change across a wide age range. Here, we examined 2-year WM change in 96 healthy adults (baseline age, 19-78 years), individual differences in change, and the influence of vascular and metabolic risk thereon. Fractional anisotropy (FA), axial diffusivity, and radial diffusivity (RD) represented microstructural properties of normal-appearing WM within 13 regions. Cross-sectional analyses revealed age-related differences in all WM indices across the regions. In contrast, latent change score analyses showed longitudinal declines in axial diffusivity in association and projection fibers and increases in anterior commissural fibers. FA and RD evidenced a less consistent pattern of change. Metabolic risk mediated the effects of age on FA and RD change in corpus callosum body and dorsal cingulum. These findings underscore the importance of longitudinal studies in evaluating individual differences in change and the role of metabolic factors in shaping trajectories of brain aging.

References

Nov 1, 1989·Neurology·A L HuntG A Rosenberg
Sep 1, 1994·Journal of Clinical Epidemiology·W A KukullM L Pfanschmidt
Apr 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Beaulieu, P S Allen
Feb 14, 1998·Neurobiology of Aging·Y TangH J Gundersen
Jun 10, 2003·The Journal of Comparative Neurology·Lisbeth MarnerBente Pakkenberg
Dec 4, 2004·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·John J McArdleMarilyn S Albert
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Aug 22, 2006·Neuroscience and Biobehavioral Reviews·Naftali Raz, Karen M Rodrigue
Apr 4, 2007·Psychological Methods·Scott E Maxwell, David A Cole
Mar 15, 2008·AJNR. American Journal of Neuroradiology·P MukherjeeR G Henry
Sep 19, 2008·Acta Neurologica Scandinavica·K HannesdottirH S Markus
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer S PerrinTomás Paus
Mar 3, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Claudia A M Wheeler-Kingshott, Mara Cercignani
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew D BuddeSheng-Kwei Song
May 1, 2009·Brain : a Journal of Neurology·Daniel BarazanyYaniv Assaf
Jul 15, 2009·Brain and Cognition·Tomás Paus

❮ Previous
Next ❯

Citations

Apr 1, 2015·Brain Imaging and Behavior·Paulo César Gonçalves MarquesNuno Jorge Carvalho Sousa
Aug 8, 2015·Neuropsychology Review·Ana M Daugherty, Naftali Raz
Apr 14, 2016·Cerebral Cortex·Anders M FjellKristine B Walhovd
Oct 22, 2016·Journal of Alzheimer's Disease : JAD·Prashanthi VemuriAnne Murray
Dec 16, 2016·Nature Communications·Simon R CoxIan J Deary
Jun 15, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chang-Woo RyuDavid H Salat
Apr 9, 2017·Human Brain Mapping·Alex Cole BirdsillAndreana Haley
Sep 29, 2018·Annals of Neurology·Prashanthi VemuriClifford R Jack
Oct 5, 2018·Frontiers in Aging Neuroscience·Katie IrwinLorina Naci
Mar 15, 2020·American Journal of Hypertension·John Richard JenningsAlan F Sved
Jul 25, 2020·European Eating Disorders Review : the Journal of the Eating Disorders Association·Nara Mendes EstellaAngélica Medeiros Claudino
Oct 27, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Frauke BeyerA Veronica Witte
Sep 19, 2017·Metabolism: Clinical and Experimental·Freddy J AlfaroVera Novak
Apr 2, 2021·Frontiers in Aging Neuroscience·Stephanie Matijevic, Lee Ryan
May 5, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christine C KwiatkowskiAlfred Jay Robison
Jun 16, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David A HoageyKristen M Kennedy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.