PMID: 6971702Apr 1, 1981Paper

Normal computed tomograms of the brain in osteosarcoma patients treated with high-dose methotrexate

Cancer
D BowlesT Coburn

Abstract

Eighteen patients with osteosarcoma, most of whom were adolescents, were examined for abnormalities of the brain by use of computed axial tomography. These studies were performed at 15-60 months (median 47 months) after the completion of adjuvant chemotherapy, which included high-dose methotrexate, cyclophosphamide, and Adriamycin. No abnormalities were found. The results of this study, together with the absence of brain lesions in published reports in children receiving high-dose methotrexate but no cranial irradiation, indicate that delayed neurotoxicity is not a major complication of this form of therapy in older children.

References

Mar 1, 1977·International Journal of Radiation Oncology, Biology, Physics·L E Kun, D Pinkel
May 1, 1978·Annals of Neurology·J C Allen, G Rosen
Jan 1, 1979·Cancer Chemotherapy and Pharmacology·W E EvansW R Crom
Jan 1, 1978·Clinical Pharmacokinetics·D D Shen, D L Azarnoff
Nov 1, 1978·Cancer·R J AurC Mason
Apr 1, 1977·Journal of Computer Assisted Tomography·N Peylan-RamuG Di Chiro
Jul 24, 1975·The New England Journal of Medicine·W R ShapiroB M Mehta
Jan 1, 1975·Cancer·J V SimoneD Pinkel
Jun 1, 1972·Archives of Disease in Childhood·H E KayE N Thompson

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