Normal development of human brain white matter from infancy to early adulthood: a diffusion tensor imaging study

Developmental Neuroscience
Satoshi UdaKyo Noguchi

Abstract

Diffusion tensor imaging (DTI), which measures the magnitude of anisotropy of water diffusion in white matter, has recently been used to visualize and quantify parameters of neural tracts connecting brain regions. In order to investigate the developmental changes and sex and hemispheric differences of neural fibers in normal white matter, we used DTI to examine 52 healthy humans ranging in age from 2 months to 25 years. We extracted the following tracts of interest (TOIs) using the region of interest method: the corpus callosum (CC), cingulum hippocampus (CGH), inferior longitudinal fasciculus (ILF), and superior longitudinal fasciculus (SLF). We measured fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity (AD), and radial diffusivity (RD). Approximate values and changes in growth rates of all DTI parameters at each age were calculated and analyzed using LOESS (locally weighted scatterplot smoothing). We found that for all TOIs, FA increased with age, whereas ADC, AD and RD values decreased with age. The turning point of growth rates was at approximately 6 years. FA in the CC was greater than that in the SLF, ILF and CGH. Moreover, FA, ADC and AD of the splenium of the CC (sCC) were greater than ...Continue Reading

Citations

Mar 8, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Andrew H CohenEmi Takahashi
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Sarah D LichensteinErika E Forbes
Nov 29, 2017·Frontiers in Human Neuroscience·Alexander J Dufford, Pilyoung Kim
Sep 16, 2017·Brain Imaging and Behavior·Sónia S SousaAdriana Sampaio
Aug 8, 2017·Human Brain Mapping·Sharissa H A CorporaalMatthieu P Boisgontier
Jul 10, 2019·Human Brain Mapping·Bryce L GeeraertCatherine Lebel
Jul 29, 2016·Journal of Neuroscience Research·Malek I Makki, Cornelia Hagmann
Jul 30, 2016·Glia·Giulia PoggiHannelore Ehrenreich
Aug 5, 2017·Frontiers in Neuroscience·Molly WilkinsonEmi Takahashi
Jul 15, 2017·European Child & Adolescent Psychiatry·Josefina Castro-FornielesElena de la Serna
Jul 16, 2016·AJNR. American Journal of Neuroradiology·S SaksenaF B Mohamed
Jan 11, 2021·Journal of Affective Disorders·Lauren R BorchersIan H Gotlib
May 14, 2021·Developmental Science·Negar FaniTanja Jovanovic
Apr 9, 2019·NeuroImage·Jess E ReynoldsCatherine Lebel

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