Normal development of the skeleton in chick limb buds devoid of dorsal ectoderm

Developmental Biology
P Martin, J H Lewis

Abstract

It has been suggested that the ectoderm on the dorsal and ventral faces of the limb bud plays a part in controlling the pattern of cartilage differentiation. To test this, the dorsal wing bud ectoderm in the chick embryo was destroyed by irradiation with ultraviolet light at stage 17-19, at the very beginning of limb bud development, but the apical ectodermal ridge was spared. The irradiated ectoderm disappeared within 24 hr (by stage 23-24) and did not regenerate thereafter; thus the dorsal surface of the limb bud was kept denuded throughout most of the period of skeletal pattern formation. By 6 or 7 days after the irradiation (stage 35), when the rudiments of all the adult skeletal elements are normally present in recognizable form, the irradiated wings could be placed into two categories, those that were approximately normal in shape and those that had curled dorsally. All of these limbs were reduced in size, to varying degrees, when compared to their controls and lacked dorsal soft tissues. The limbs that were normal in shape, however, even though sometimes denuded over practically the whole extent of their dorsal surface, almost always had a complete and normally proportioned cartilage pattern, suggesting that ectoderm (ot...Continue Reading

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Citations

Dec 12, 2012·Mathematical Biosciences·Yong-Tao ZhangStuart A Newman
Mar 9, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sevan HopyanYingzi Yang
Jul 16, 2013·Developmental Biology·Marian Fernandez-TeranFrancesca V Mariani
Nov 1, 1989·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P M Brickell, C Tickle

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