PMID: 59078Jul 3, 1976

"Normal" elimination of aberrant autoimmune clones

Lancet
R D Barnes, E J Wills

Abstract

Tetraparental mouse chimaeras formed by aggregation of early embryos have been utilised in the study of immunological mechanisms. Tolerance in chimaeras has proven somewhat controversial, but recent evidence has suggested the existence of "classic" tolerance and furthermore that this is achieved by elimination of cells potentially capable of fatal self in equilibrium self reactivity. Clonal elimination was also considered to be responsible for the "correction" of the autoimmune disease of NZB mice made chimaeric with a normal strain. It is now suggested that a similar mechanism may be responsible for the "normal" elimination of any aberrant autoimmune clone in both mouse and man.

References

Jul 1, 1978·Seminars in Hematology·K A DickeK B McCredie
Jun 13, 1973·Nature: New Biology·M TuffreyC E Ford
Dec 15, 1967·Science·B Mintz, W K Silvers
Jun 3, 1961·Nature·A K TARKOWSKI
May 7, 1976·Science

Citations

Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·S D FlynnS T Bigos
Mar 1, 1986·Journal of the Royal Society of Medicine·J S ShaheenA Marvasti

Related Concepts

Antibody Formation
Autoantibodies
Autoantigens
Autoimmune Diseases
Chimera Organism
Natural Immunosuppression
Mice, Inbred NZB
Mosaicism
Phagocytosis
T-Lymphocyte

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