Normal erythropoietic helper T cells in congenital hypoplastic (Diamond-Blackfan) anemia

The New England Journal of Medicine
D G NathanD E Housman


To examine the erythropoietic function of T and null cells in congenital hypoplastic (Diamond-Blackfan) anemia, we fractionated the peripheral blood of three normal subjects and three affected patients into subclasses of null, T and B cells. Mixtures of these cells were co-cultured in plasma clots in the presence of erythropoietin. Erythroid colonies grew in cultures of normal null cells if either normal or patient T cells were co-cultured with them. Null cells of patients with hypoplastic anemia did not produce erythroid colonies under any culture conditions. We conclude that in this disorder, T cells function normally as helper cells in erythropoiesis and do not suppress colony formation, whereas the erythroid progenitor cells in the peripheral blood null-cell fractions are deficient in either number of function.


Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B Clarke, D E Housman
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T PapayannopoulouG Stamatoyannopoulos
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G R Johnson, D Metcalf
Feb 1, 1978·The Journal of Experimental Medicine·D G NathanD E Housman
Feb 1, 1978·The Journal of Clinical Investigation·D G NathanD E Housman
Jan 6, 1977·The New England Journal of Medicine·R HoffmanL R Wasserman
Mar 1, 1976·The Journal of Clinical Investigation·M H FreedmanE F Saunders
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J R StephensonM M Shreeve


Aug 1, 1990·European Journal of Pediatrics·S Miceli SopoA Stabile
Dec 15, 1983·The New England Journal of Medicine·B E GladerL K Diamond
Apr 25, 2000·Journal of Pediatric Hematology/oncology·A J AlessandriJ H Davis
Apr 1, 1992·Acta Paediatrica Japonica; Overseas Edition·S SumimotoT Hamamoto
Apr 1, 1979·Archives of Disease in Childhood·B P Alter, D G Nathan
Sep 1, 1982·The Journal of Clinical Investigation·J L FinlayR Hong
Feb 1, 1982·Environmental Health Perspectives·G A BoormanM L Campbell
Mar 26, 2011·Seminars in Hematology·Anupama NarlaD G Nathan
Aug 1, 1995·The Central African Journal of Medicine·P Jacobs
Sep 1, 1989·British Journal of Haematology·P H TsaiJ M Lipton
Jan 1, 1989·Baillière's Clinical Haematology·D I Evans
Jan 27, 1998·Hematology/oncology Clinics of North America·O I Krijanovski, C Sieff
Oct 13, 2000·Baillière's Best Practice & Research. Clinical Haematology·M H Freedman
Sep 1, 1985·Clinical Immunology and Immunopathology·A P Knutsen, D M O'Connor
Sep 1, 1984·Clinical Pediatrics·K H Lazarus, F A McCurdy
Jan 1, 1981·American Journal of Medical Genetics·R E HarrisM E Hodes
Feb 1, 1990·American Journal of Medical Genetics·D H ViskochilR D Christensen
Mar 1, 1987·American Journal of Hematology·S S Ammus, A A Yunis
Jan 1, 1978·American Journal of Hematology·J H Fitchen, M J Cline
Jul 1, 1983·British Journal of Haematology·C Sieff

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Hypoplastic Anemia
Lymphocyte Cooperation

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