Normal fasting plasma glucose and risk of prediabetes and type 2 diabetes: the Isfahan Diabetes Prevention Study.

The Review of Diabetic Studies : RDS
Mohsen Janghorbani, Masoud Amini

Abstract

To determine the association of fasting plasma glucose (FPG) level within normal range and the risk of prediabetes and type 2 diabetes in an Iranian population. A total of 806 first-degree relatives (FDRs) of patients with type 2 diabetes who had FPG levels less than 5.6 mmol/l (100 mg/dl) in 2003 to 2005, and who did not have diabetes or impaired fasting glucose (IFG), were followed through 2010 for the occurrence of prediabetes or type 2 diabetes. At baseline and through follow-ups, participants underwent a standard 75 g 2-hour oral glucose tolerance test (OGTT). The incidence of type 2 diabetes, impaired glucose tolerance (IGT), and IFG was 9.6 (95% confidence interval (CI): 6.8-12.4), 28.7 (23.8-33.6), and 33.0 (27.7-38.2) per 1,000 person-years based on 4,489 person-years of follow-up, respectively. FPG was associated with the incidence of diabetes, IGT, and IFG. The multivariate-adjusted hazard ratios (95% CI) for diabetes, IGT, and IFG were 1.36 (1.01-1.84), 1.45 (1.10-1.91) and 1.31 (1.00-1.71), for the highest quintile of FPG compared with the lowest quintile, respectively. An increase in FPG in the normal range is associated with an increase in the incidence of IGT, IFG, and type 2 diabetes. These results prove FPG in...Continue Reading

References

Jun 17, 2000·Diabetes Care·J E ShawK G Alberti
Feb 28, 2001·Diabetes, Obesity & Metabolism·A RamachandranV Vijay
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
Nov 25, 2003·Diabetes Care·Mayer B DavidsonCharles M Alexander
Oct 7, 2005·The New England Journal of Medicine·Amir TiroshUNKNOWN Israeli Diabetes Research Group
May 27, 2008·The American Journal of Medicine·Gregory A NicholsJonathan B Brown
Dec 3, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·M A Abdul-GhaniR A DeFronzo
Oct 29, 2009·Diabetes/metabolism Research and Reviews·Mohsen Janghorbani, Masoud Amini
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Apr 19, 2011·Diabetes Care·Paolo BrambillaPaolo Mocarelli
May 10, 2011·Acta Diabetologica·Mustafa KanatMuhammad A Abdul-Ghani

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Citations

Nov 19, 2015·QJM : Monthly Journal of the Association of Physicians·Chia-Luen HuangChang-Hsun Hsieh
Oct 3, 2015·Journal of Education and Health Promotion·Tayyebeh ChahkandiMahmoud Zardast
Oct 30, 2018·The Cochrane Database of Systematic Reviews·Bernd RichterYemisi Takwoingi
Feb 6, 2020·Current Medical Imaging Reviews·Safia Naveed, Gurunathan Geetha

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