Normal fluid stresses are prevalent in rotary ventricular assist devices: A computational fluid dynamics analysis

The International Journal of Artificial Organs
Dominica Py KhooKatharine H Fraser

Abstract

Despite the evolution of ventricular assist devices, ventricular assist device patients still suffer from complications due to the damage to blood by fluid dynamic stress. Since rotary ventricular assist devices are assumed to exert mainly shear stress, studies of blood damage are based on shear flow experiments. However, measurements and simulations of cell and protein deformation show normal and shear stresses deform, and potentially damage, cells and proteins differently. The aim was to use computational fluid dynamics to assess the prevalence of normal stress, in comparison with shear stress, in rotary ventricular assist devices. Our calculations showed normal stresses do occur in rotary ventricular assist devices: the fluid volumes experiencing normal stress above 10 Pa were 0.011 mL (0.092%) and 0.027 mL (0.39%) for the HeartWare HVAD and HeartMate II (HMII), and normal stresses over 100 Pa were present. However, the shear stress volumes were up to two orders of magnitude larger than the normal stress volumes. Considering thresholds for red blood cell and von Willebrand factor deformation by normal and shear stresses, the fluid volumes causing deformation by normal stress were between 2.5 and 5 times the size of those cau...Continue Reading

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Citations

Mar 9, 2019·Biomechanics and Modeling in Mechanobiology·Mohammad M Faghih, M Keith Sharp
Aug 8, 2019·Biomechanics and Modeling in Mechanobiology·Mohammad M Faghih, M Keith Sharp
Mar 7, 2021·Cardiovascular Engineering and Technology·Lucas KonnigkFrank-Hendrik Wurm
Jun 10, 2021·Biomechanics and Modeling in Mechanobiology·Mesude AvciDimitrios V Papavassiliou
Jan 9, 2022·Scientific Reports·Oanh L PhamDimitrios V Papavassiliou

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