Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene

Gene
C LuoA Rao

Abstract

NFAT1 (NFATp), a cytosolic component of the nuclear factor of activated T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein. The NFAT1 protein in wasted mice is properly regulated and possesses comparable DNA binding activity as that in their littermate controls. Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein.

References

Apr 1, 1991·Trends in Genetics : TIG·N G Copeland, N A Jenkins
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·K T ShawP G Hogan
Feb 24, 1995·The Journal of Biological Chemistry·J JainA Rao
Jul 1, 1994·Molecular Immunology·C R LibertinG E Woloschak

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Citations

Jul 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M K DuncanS I Tomarev
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·C López-RodríguezA Rao
Oct 3, 1998·Cellular Immunology·M PotterJ M Lee
Jan 1, 1997·Annual Review of Immunology·A RaoP G Hogan

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