Normal glomerular filtration rate in long-term follow-up of children after orthotopic liver transplantation

Transplantation
Denise HerzogFernando Alvarez

Abstract

Cyclosporine A (CyA) and tacrolimus are the principal immunosuppressive agents used for OLT in children. However, progressive deterioration of renal function from calcineurin inhibitor toxicity after OLT has been widely reported. The aim of this study was to assess long-term renal function in children after OLT. We reviewed all OLT patients surviving >1 year at Sainte Justine Hospital from 1987 to 2003. The GFR (ml/min/1.73 m) was measured yearly by the Tc-99m DTPA single injection technique In all, 101 OLT patients (27 tyrosinemia, 33 biliary atresia, 5 fulminant hepatic failure, 36 miscellaneous) were studied. Median age at OLT was 35 months (range 6-178 months) in tyrosinemia group and 58 months (range 1-226 months) in the "Others" (P = NS), median pediatric end-stage liver disease score was respectively 3 (range -9 to 21) and 15 (-9 to 35), (P=0.001), and median follow-up was 6 (range 1-14) and 6 (range 1-17) (P = NS) years, respectively. Median annual GFR values in tyrosinemia fluctuated between 61 and 104 ml/min/1.73 m, with an improving tendency, and 94-121 ml/min/1.73 m in the Others. GFR did not differ on CyA vs. tacrolimus treatment. The median duration of therapy with calcium-channel blocker in the tyrosinemia group ...Continue Reading

References

Jul 1, 1992·Clinical Nuclear Medicine·K C SekarJ C Duke
Dec 1, 1994·The Journal of Pediatrics·J LaineC Holmberg
Jan 1, 1996·European Journal of Nuclear Medicine·R D GunasekeraA M Peters
Nov 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M al EdreesiK Paradis
Aug 6, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L J PetersenH A Jensen
Dec 22, 1999·European Journal of Pediatrics·N MohanD A Kelly
Nov 2, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·T A Gonwa
Oct 3, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ari J CohenNizar N Zein
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Attaphol PawarodePaul J Thuluvath
Sep 5, 2003·The New England Journal of Medicine·Akinlolu O OjoRobert M Merion
Mar 31, 2004·Pediatric Transplantation·Nitika Arora-GuptaDeirdre A Kelly

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Citations

May 30, 2008·Journal of Inherited Metabolic Disease·S SantraP J McKiernan
Mar 30, 2012·Journal of Inherited Metabolic Disease·David C BartlettPatrick J McKiernan
May 22, 2007·Current Gastroenterology Reports·William R Treem
Oct 24, 2008·Transplantation·Jérôme HarambatPierre Cochat
Apr 1, 2011·Transplantation·Jesper M KiveläJouni Lauronen
Jun 18, 2009·World Journal of Gastroenterology : WJG·Jing LiFu-Gui Li
Aug 8, 2008·Current Opinion in Organ Transplantation·John C Bucuvalas, Estella Alonso
Aug 25, 2010·Current Opinion in Organ Transplantation·Kathleen M Campbell, John C Bucuvalas
Mar 8, 2011·Clinics and Research in Hepatology and Gastroenterology·Ahmed A DarwishChristophe Chardot
Apr 8, 2010·Pediatric Clinics of North America·Monique ChoquetteKathleen M Campbell
Apr 9, 2008·Seminars in Pediatric Surgery·Frederick C RyckmanWilliam F Balistreri
Apr 20, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C MonchaudE Jacqz-Aigrain
Nov 27, 2015·Pediatric Transplantation·Mukadder Ayşe SelimoğluSezai Yılmaz
Jul 2, 2009·Pediatric Transplantation·Srinivas P ChavaNigel D Heaton
Aug 5, 2008·Pediatric Transplantation·Jonathan R BishopPatricia McClean
Nov 8, 2012·Pediatric Transplantation·Robyn Greenfield MatloffJeffrey M Saland
Dec 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K CampbellUNKNOWN SPLIT Renal Function Working Group
May 30, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Emily Rothbaum PeritoPhilip Rosenthal
Mar 25, 2010·Pediatric Transplantation·Gustaf HerleniusStyrbjörn Friman
Apr 13, 2013·Journal of Hepatology·Stefano FagiuoliGiuseppe Remuzzi
Aug 21, 2015·Current Gastroenterology Reports·Robyn Greenfield Matloff, Ronen Arnon
Dec 19, 2008·Journal of the American Society of Nephrology : JASN·Jeffrey M SalandUNKNOWN Consensus Study Group
May 28, 2020·Pediatric Transplantation·Ruben Peña ZavalaFernando Alvarez
Sep 20, 2020·Clinical Transplantation·Antonio LacquanitiPaolo Monardo
Sep 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Florian BrinkertRainer Ganschow
Dec 3, 2008·Pediatrics·Vicky Lee NgUNKNOWN Studies of Pediatric Liver Transplantation Research Group

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