Normal growth hormone secretory reserve in men with idiopathic osteoporosis and reduced circulating levels of insulin-like growth factor-I

The Journal of Clinical Endocrinology and Metabolism
E S KurlandJ P Bilezikian

Abstract

Many men with idiopathic osteoporosis have reduced circulating insulin-like growth factor-I (IGF-I) levels. The major source of circulating IGF-I is GH-mediated production by the liver. The known anabolic effects of GH on the skeleton raised the possibility of GH deficiency in these men. We sought to test this hypothesis in this study. Fourteen men (mean age, 52.1 +/- 3.2 yr, range 31-68) with idiopathic osteoporosis were studied. Mean lumbar spine bone mineral density (BMD) was 0.723 g/cm2, T score -3.5; femoral neck BMD was 0.642 g/cm2, T score, -3.07; distal (1/3) radius BMD was 0.708 g/cm2, T score, -2.05. Eleven of 14 (79%) had frank reductions in serum IGF-I levels compared with age and sex-matched values (158.5 +/- 50 SD vs. 180 +/- 45 SD). GH secretion was stimulated by iv arginine infusion (30 g) over 30 min followed 1 h later by oral L-dopa (500 mg). Serum GH was measured at time (t) = -15, 0, 30, 45, 60, 90, 120, 150, and 180 min. All patients responded to at least one stimulus with the majority (n = 9) responding to both. Five patients responded either to arginine or to L-dopa but not to both. Baseline GH for the entire group was 0.77 + 0.08 ng/mL (SEM). Peak GH following arginine (t = 45-60 min) was 14.0 +/- 2.8 ng...Continue Reading

Citations

Dec 18, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A M DelanyE S Kurland
May 3, 2008·Endocrine Reviews·Sundeep KhoslaEric Orwoll
Apr 18, 2007·Current Rheumatology Reports·Luigi Gennari, John P Bilezikian
Apr 20, 2001·Calcified Tissue International·P GillbergS Ljunghall
Jul 1, 2009·Endocrine Journal·Renata Francioni LopesMaria Lucia Fleiuss de Farias
Feb 27, 2007·Current Osteoporosis Reports·Luigi Gennari, John P Bilezikian
Sep 21, 2013·Current Osteoporosis Reports·Luigi Gennari, John P Bilezikian
Oct 31, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Laure Dossus, Rudolf Kaaks

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