'Normal' haemostasis parameters: a study in a well-defined inborn population of preterm infants

Early Human Development
D W BeverleyB O'Keefe

Abstract

Coagulation studies were performed in a well-defined inborn population of preterm neonates in cord blood and arterial blood obtained at age 48 h. Eighty infants fulfilled all the inclusion criteria. Our results show an increase in the hepatic vitamin K1 dependent and independent factors with postnatal age. The APTT became shorter, the factor II-VII-X, alpha 2-antiplasmin, plasminogen activities and fibrinogen level rose with increasing postnatal age. We found no change in the platelet parameters measured with postnatal age except that the megathrombocyte index was increased at age 48 h in infants less than 29 weeks gestation. There was little change with gestational age of any factors except the vitamin K1 dependent factors. Factor II-VII-X activity rose and the APTT became shorter with increasing gestational age. Many of the haemostasis results did not fall within the normal adult range. We discuss the significance of 'abnormal' and 'normal' results in preterm infants.

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Citations

Mar 25, 1998·Journal of Biomedical Materials Research·E A VoglerJ C Graper
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S HirosawaK Kurachi
Sep 27, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·S E WiedmeierR D Christensen
Jan 27, 2009·Seminars in Perinatology·Robert D ChristensenSusan E Wiedmeier
Mar 10, 2012·Journal of Thrombosis and Haemostasis : JTH·V IgnjatovicUNKNOWN Perinatal and Paediatric Haemostasis Subcommittee of the Scientific and Standardization Committee of the International Socie
May 1, 1984·Archives of Disease in Childhood·D W BeverleyB O'Keefe
Sep 5, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Kirstin FaustChristoph Härtel
Jan 1, 1990·Journal of Perinatal Medicine·D KoheletM Goldberg

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