Normal neuropsychological development in children with congenital complete heart block who may or may not be exposed to high-dose dexamethasone in utero

Annals of the Rheumatic Diseases
A BrucatoS Martinelli

Abstract

Antenatal and postnatal treatment with dexamethasone (DEX) may negatively affect the neuropsychological development in children. Maternal anti-Ro/Sjögren's syndrome A (SSA) antibodies may also be associated with learning disabilities in offspring. To assess neuropsychological development in babies exposed to very high dosages of DEX in utero, whose mothers were anti-Ro/SSA positive. 13 children with congenital complete heart block (CHB) (11 exposed and 2 not exposed to DEX) and 3 healthy siblings, all of anti-Ro/SSA-positive women, were evaluated. 11 preschool-aged children (5 boys) were assessed using Griffiths Mental Development Scales. 5 school-aged children (2 boys) were examined using Wechsler Intelligence Scale for Children-Revised to check IQ and reading tests to explore the existence of learning disabilities or dyslexia. None of the children had had major neonatal complications, although those with CHB had to be paced at different intervals from birth. The children had been exposed in utero to a mean total dose of 186.6 mg DEX. IQ levels were always normal (mean IQ 105.1, standard deviation (SD) 9.5). Only one child had a learning disability, of borderline clinical significance, but this child had never been exposed to ...Continue Reading

References

Jun 3, 1998·American Journal of Obstetrics and Gynecology·A H JobeM G Ervin
Jan 23, 1999·American Journal of Obstetrics and Gynecology·N P FrenchJ P Newnham
Sep 24, 1999·British Journal of Obstetrics and Gynaecology·P BrocklehurstG Chamberlain
Mar 10, 2000·Pediatric Research·S G Matthews
May 20, 2000·American Journal of Obstetrics and Gynecology·S AbbasiJ S Gerdes
Jun 30, 2001·Obstetrics and Gynecology·UNKNOWN National Institutes of Health Consensus Development Panel
Jul 27, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·W L HuangS A Dunlop
Apr 16, 2003·Archives of Pediatrics & Adolescent Medicine·Gail RossMichael Lockshin
May 1, 2004·American Journal of Obstetrics and Gynecology·Alan H Jobe, Roger F Soll
Jun 1, 2005·Rheumatic Diseases Clinics of North America·Jill P Buyon, Robert M Clancy
Jun 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Remigiusz UrbanMałgorzata Kretowska
Oct 13, 2005·Lupus·N Costedoat-ChalumeauJ C Piette

❮ Previous
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Citations

Dec 17, 2009·Clinical Reviews in Allergy & Immunology·Antonio BrucatoJill Buyon
Nov 26, 2010·Rheumatology·Monika OstensenMaurizio Cutolo
Dec 27, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Takekazu MiyoshiTomoaki Ikeda
Jun 20, 2014·Mayo Clinic Proceedings·Linda B Drozdowicz, J Michael Bostwick
Sep 9, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Roland WeberEdgar Jaeggi
Feb 5, 2008·Best Practice & Research. Clinical Obstetrics & Gynaecology·Olus Api, Julene S Carvalho
Mar 25, 2008·Pacing and Clinical Electrophysiology : PACE·Edgar T Jaeggi, Mark K Friedberg
Apr 5, 2013·Acta Paediatrica·Amanda SkogMarie Wahren-Herlenius
Jul 3, 2015·Journal of the Saudi Heart Association·Lindsey E Hunter, John M Simpson
Apr 7, 2009·American Journal of Obstetrics and Gynecology·Enrico LoprioreFrank P H A Vandenbussche
Dec 30, 2011·Journal of Autoimmunity·Laura AndreoliAngela Tincani
Jul 21, 2009·Brain & Development·Naomi YoshikawaToshiaki Shimizu
Sep 22, 2009·Early Human Development·Mario MottaGaetano Chirico
Jan 15, 2016·Lupus·P Brito-ZerónM A Khamashta
Dec 13, 2006·Lupus·A TincaniUNKNOWN Pregancy Study Group of Italian Socitety of Rheumatology
Jul 27, 2007·Fetal Diagnosis and Therapy·Johannes M P J BreurErik J Meijboom
Jun 13, 2019·Nature Reviews. Rheumatology·Ian GilesCaroline Gordon
Jan 9, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S-E SonessonM Wahren-Herlenius
Nov 20, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yuka Sano WadaAtsuko Murashima
Feb 19, 2021·Expert Opinion on Drug Safety·Anna Viola TaulaigoLaura Andreoli
Sep 11, 2007·Seminars in Perinatology·Federico MecacciMichael J Paidas

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