Normal on-treatment ALT during antiviral treatment is associated with a lower risk of hepatic events in patients with chronic hepatitis B

Journal of Hepatology
Grace Lai-Hung WongVincent Wai-Sun Wong

Abstract

Recent studies reveal that the rate of normal on-treatment alanine aminotransferase (ALT) appears different for different nucleos(t)ide analogues (NAs); yet its clinical significance is unclear. We aimed to evaluate the impact of normal on-treatment ALT during antiviral treatment with entecavir (ETV) or tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB). A territory-wide cohort of patients with CHB who received ETV and/or TDF in 2005-2016 was identified. Serial on-treatment ALT levels were collected and analyzed. Normal on-treatment ALT (ALT-N) was defined as ALT <30 U/L in males and <19 U/L in females. The primary and secondary outcomes were composite hepatic events (including hepatocellular carcinoma) based on diagnostic codes. Patients with hepatic events before or during the first year of antiviral treatment or follow-up <1 year were excluded. A total of 21,182 patients with CHB (10,437 with and 10,745 without ALT-N at 12 months after antiviral treatment) were identified and followed for 4.0 ± 1.7 years. Patients with and without ALT-N differed in baseline ALT (58 vs. 61 U/L), hepatitis B virus DNA (4.9 vs. 5.1 log10 IU/ml) and cirrhosis status (8.8% vs. 10.5%). A total of 627 (3.0%) patients dev...Continue Reading

Citations

Sep 5, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Grace Lai-Hung WongVincent Wai-Sun Wong
Nov 30, 2018·Alimentary Pharmacology & Therapeutics·Grace Lai-Hung WongVincent Wai-Sun Wong
Feb 14, 2019·Clinical and Molecular Hepatology·Lilian Yan Liang, Grace Lai-Hung Wong
Dec 28, 2019·Alimentary Pharmacology & Therapeutics·Terry C-F Yip, Grace L-H Wong
Dec 18, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Grace L-H WongVincent W-S Wong
Jul 24, 2018·Therapeutic Advances in Gastroenterology·Ruth ByrneKosh Agarwal
Jun 27, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Grace Lai-Hung WongHenry Lik-Yuen Chan
Jul 16, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Wanying LiJian Sun
Oct 13, 2020·Journal of Gastroenterology and Hepatology·Terry Cheuk-Fung Yip, Grace Lai-Hung Wong
Feb 23, 2021·Therapeutic Advances in Infectious Disease·Luisa RoadeMaria Buti
Feb 2, 2021·Clinical and Molecular Hepatology·Terry Cheuk-Fung YipVincent Wai-Sun Wong
Mar 12, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hidenori ToyodaMindie H Nguyen
Feb 10, 2021·The American Journal of Gastroenterology·Grace Lai-Hung WongStephen Lam Chan
Dec 8, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Pimsiri SripongpunPaul Y Kwo
Feb 2, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David PetroffJohannes Wiegand
Sep 4, 2021·Journal of Gastroenterology and Hepatology·Young Eun ChonBeom Kyung Kim
Mar 19, 2021·The American Journal of Gastroenterology·Heechul NamJeong Won Jang
Oct 23, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Si Ho KimEun Sun Jang

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