PMID: 16538111Mar 16, 2006Paper

Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption

European Journal of Gastroenterology & Hepatology
Antal BajorKjell-Arne Ung

Abstract

Bile acid malabsorption as reflected by an abnormal Se-labelled homocholic acid-taurine (SeHCAT) test is associated with diarrhoea, but the mechanisms and cause-and-effect relations are unclear. Primarily, to determine whether there is a reduced active bile acid uptake in the terminal ileum in patients with bile acid malabsorption. Secondarily, to study the linkage between bile acid malabsorption and hepatic bile acid synthesis. Ileal biopsies were taken from patients with diarrhoea and from controls with normal bowel habits. Maximal active bile acid uptake was assessed in ileal biopsies using a previously validated technique based on uptake of C-labelled taurocholate. To monitor the hepatic synthesis, 7alpha-hydroxy-4-cholesten-3-one, a bile acid precursor, was assayed in blood. The SeHCAT-retention test was used to diagnose bile acid malabsorption. The taurocholate uptake in specimens from diarrhoea patients was higher compared with the controls [median, 7.7 (n=53) vs 6.1 micromol/g per min (n=17)] (P<0.01) but no difference was seen between those with bile acid malabsorption (n=18) versus diarrhoea with a normal SeHCAT test (n=23). The SeHCAT values and 7alpha-hydroxy-4-cholesten-3-one were inversely correlated. The data do ...Continue Reading

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Citations

Nov 9, 2010·Inflammatory Bowel Diseases·Martin LenicekLibor Vitek
Jun 7, 2013·European Journal of Nuclear Medicine and Molecular Imaging·A Michael Peters, Julian R F Walters
Aug 2, 2011·Current Gastroenterology Reports·Ian JohnstonJulian R F Walters
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Mar 26, 2010·Scandinavian Journal of Gastroenterology·Antal BajorHasse Abrahamsson
Aug 12, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alan F HofmannSteven A Kliewer
May 12, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Julian R F WaltersCarel W le Roux
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