Normal postnatal development of medial superior olivary neurons in the albino rat: a Golgi and Nissl study

The Journal of Comparative Neurology
B A Rogowski, A S Feng

Abstract

Bipolar neurons in the medial superior olivary (MSO) nucleus of albino rats were studied at various ages (0-75 days) during development in order to elucidate normal neuronal growth patterns. Neurons, visualized in celloidin embedded Golgi/Nissl- and frozen Nissl-stained sections, were analyzed quantitatively for cell size and extent of dendritic arborization. These parameters, from both sets of data, showed a consistent developmental trend with the existence of two major stages in the ontogenetic process: a rapid developmental and a stabilization stage. The first stage, encompassing postnatal days 0 through approximately 14, was characterized by a rapidly increasing cell size, as observed in frozen sections. At the peak of this rapid growth, Golgi-stained neurons possessed thick dendrites with many appendages, growth cones, and filopodia. The peak in neuronal development coincided with the initiation of ear opening. Morphological features attained a more mature form in the second, stabilizing stage of development, which began at approximately postnatal day 14. This phase was distinguished by a decrement in cell size and dendritic branching. Also, dendrites possessed more regularly distributed varicosities and fewer appendages, ...Continue Reading

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May 22, 1992·Brain Research. Developmental Brain Research·D H SanesJ Tyson
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