Normal protein diet for episodic hepatic encephalopathy: results of a randomized study

Journal of Hepatology
Juan CórdobaJaume Guardia

Abstract

Protein-restricted diets are usually prescribed for cirrhotic patients with hepatic encephalopathy. However, protein restriction may worsen the nutritional status without resulting in an improvement of hepatic encephalopathy. We designed a study to assess the effects of the amount of protein in the diet on the evolution of episodic hepatic encephalopathy. Cirrhotics admitted to the hospital because of an episode of encephalopathy (n=30) were randomized to receive a low-protein diet with progressive increments or a normal protein diet for 14 days, in addition to standard measures to treat hepatic encephalopathy. Protein synthesis and breakdown were studied at day 2 and day 14 with the glycine-N(15) infusion method. The outcome of hepatic encephalopathy was not significantly different between both groups of treatment. Protein synthesis was similar for low and normal protein diet, but those of the low-protein diet group showed higher protein breakdown. Diets with a normal content of protein, which are metabolically more adequate, can be administered safely to cirrhotic patients with episodic hepatic encephalopathy. Restriction of the content of protein of the diet does not appear to have any beneficial effect for cirrhotic patient...Continue Reading

References

Jan 1, 1992·Gastroenterology·P J KearnsP Gregory
Nov 11, 1991·Seminars in Liver Disease·K D Mullen, F L Weber
Jan 1, 1995·Journal of Hepatology·M J Müller
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MerliL Dally
Aug 1, 1996·Seminars in Liver Disease·R F Butterworth
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O SelbergM J Müller
Feb 1, 1997·The British Journal of Nutrition·J KondrupA Juul
Aug 14, 1997·The New England Journal of Medicine·S M Riordan, R Williams
Jul 1, 1997·Journal of Hepatology·J Kondrup, M J Müller
May 20, 1999·BMJ : British Medical Journal·C A Seymour, K Whelan
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·N E DeutzP B Soeters
Jul 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A J McCullough
Jul 27, 2001·The American Journal of Gastroenterology·A T BleiUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter FerenciAndres T Blei
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven W M Olde DaminkPeter B Soeters
Jun 14, 2003·Gastroenterology·Giulio MarchesiniUNKNOWN Italian BCAA Study Group
Dec 1, 1989·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·G R SwartM Frenkel
Apr 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M PlauthUNKNOWN ESPEN Consensus Group
Apr 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J López-HellinS Schwartz

❮ Previous
Next ❯

Citations

May 18, 2013·Medizinische Klinik, Intensivmedizin und Notfallmedizin·M Plauth
Nov 4, 2006·Current Treatment Options in Gastroenterology·Nader Dbouk, Brendan M McGuire
Feb 1, 2005·Lancet·Debbie Shawcross, Rajiv Jalan
Jan 8, 2010·The New England Journal of Medicine·Corey S ScurlockJeffrey Mechanick
Nov 20, 2009·The New England Journal of Medicine·Peter C Gøtzsche, Helle K Johansen
Jan 1, 2009·Journal of Palliative Medicine·Julie Wilson Childers, Robert M Arnold
Jun 16, 2010·Journal of Gastroenterology and Hepatology·Hisataka MoriwakiYoichi Terakura
Jul 20, 2012·International Journal of Hepatology·Amar Nath MukerjiAshokkumar Jain
Feb 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Giannakis T TorisStamatios E Theocharis
Aug 27, 2009·Therapeutics and Clinical Risk Management·Mohamad Rasm Al Sibae, Brendan M McGuire
Aug 8, 2013·International Journal of Molecular Sciences·Liliana Rivera-EspinosaLiliana Carmona-Aparicio
Jul 16, 2010·World Journal of Gastroenterology : WJG·Amit S SeyanDebbie L Shawcross
May 17, 2014·World Journal of Gastroenterology : WJG·Salman NusratMohammad F Madhoun
May 26, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Hanan A Alfawaz, Abdulrahman A Aljumah
Jan 15, 2011·Journal of Nutrition and Metabolism·Chantal BémeurRoger F Butterworth
Sep 26, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Wissam Bleibel, Abdullah M S Al-Osaimi
Dec 20, 2014·Hepatology International·Douglas L Nguyen, Timothy Morgan
Oct 11, 2014·Inflammopharmacology·Christopher SheasgreenAmeen Patel
May 9, 2014·Current Treatment Options in Neurology·Jennifer A Frontera
Nov 12, 2009·QJM : Monthly Journal of the Association of Physicians·W J CashN I McDougall
Aug 28, 2010·Indian Journal of Pediatrics·Vidyut Bhatia, Rakesh Lodha
Jan 26, 2016·Current Medical Research and Opinion·Dmitry Victorovich Garbuzenko
Dec 29, 2015·International Journal of Clinical Practice·V RosatoM Persico
Jan 15, 2014·Mayo Clinic Proceedings·Michael D LeiseW Ray Kim
Nov 26, 2013·The Medical Clinics of North America·Iris W Liou
Jul 3, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwani K SingalVijay H Shah
Oct 30, 2012·Clinics in Liver Disease·Ashwani K Singal, Michael R Charlton
May 1, 2012·Clinics in Liver Disease·Vandana Khungar, Fred Poordad
Feb 11, 2012·Clinics in Liver Disease·Vandana Khungar, Fred Poordad
Oct 29, 2011·Clinics in Liver Disease·Hui-Hui Tan, Paul Martin
Sep 7, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kally CheungMaitreyi Raman
Sep 2, 2010·The Nursing Clinics of North America·Lissi HansenBetsy Zucker
Aug 10, 2010·Critical Care Nursing Clinics of North America·Vivian M Zhao, Thomas R Ziegler
Dec 17, 2009·Gastroenterología y hepatología·Angels Escorsell Mañosa, Antoni Mas Ordeig
Mar 10, 2009·Medicina clínica·Juan Córdoba Cardona
Jul 7, 2009·The Medical Clinics of North America·Vinay Sundaram, Obaid S Shaikh
Jun 24, 2008·Disease-a-month : DM·Mamie H Dong, Sammy Saab
Jun 24, 2008·The Medical Clinics of North America·Santiago J Munoz
Mar 8, 2016·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Joseph R SweigartAlla Y Grigorian
May 13, 2008·Gastroenterology·Arun J SanyalVincente Arroyo
May 13, 2008·Gastroenterology·Alastair O'Brien, Roger Williams
Jan 16, 2007·Best Practice & Research. Clinical Gastroenterology·Gavin Wright, Rajiv Jalan
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lars Marius YtrebøChristopher F Rose
Sep 5, 2007·Alimentary Pharmacology & Therapeutics·M OrtizJ Guardia
Oct 2, 2015·Lancet·William BernalAndrew Burroughs
Jan 8, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Giampaolo BianchiGiulio Marchesini
Mar 9, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Piero AmodioMarsha Y Morgan
Feb 26, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Manuela MerliMaurizio Muscaritoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
M PlauthESPEN (European Society for Parenteral and Enteral Nutrition)
QJM : Monthly Journal of the Association of Physicians
D K KocharT Srivastava
© 2022 Meta ULC. All rights reserved