PMID: 11328682May 1, 2001Paper

Normal spatial memory following postseizure treatment with ketamine: selective damage attenuates memory deficits in brain-damaged rodents

The International Journal of Neuroscience
S A SantiR P O'Connor

Abstract

Within 30 min after the initiation of status epilepticus (SE) by lithium and pilocarpine, rats were injected with either acepromazine or ketamine. Compared to the rats that had received the acepromazine, the group that had received the ketamine displayed more accurate spatial memory. Their scores did not differ significantly from normal (non-seized) controls. Although the ketamine treatment did not significantly change the amount of neuronal loss within about 100 Paxinos and Watson structures, it was neuroprotective for several structures within the thalamus and portions of the temporal and parietal cortices. Ketamine-treated rats, however, displayed markedly more damage within the entorhinal cortices and amygdalohippocampal area.

References

Mar 1, 1979·Behavioral and Neural Biology·M A Persinger
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·D C McIntyre, J R Plant
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine

❮ Previous
Next ❯

Citations

Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·M A PersingerY R J Bureau
Apr 23, 2013·CNS Neuroscience & Therapeutics·Frederic DorandeuGuy Testylier
May 26, 2004·Pharmacology, Biochemistry, and Behavior·B E McKay, M A Persinger
May 18, 2007·The International Journal of Neuropsychopharmacology·Konstantinos N FountoulakisHagop Akiskal
Jan 1, 2011·The Neurohospitalist·Edward M Manno
Feb 23, 2020·The International Journal of Neuroscience·Fatma TannichOuajdi Souilem

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.