Normal-Tension Glaucoma Has Normal Intracranial Pressure: A Prospective Study of Intracranial Pressure and Intraocular Pressure in Different Body Positions

Ophthalmology
Christina LindénAnders Eklund

Abstract

To test the hypothesis that normal-tension glaucoma (NTG) is caused by an increased pressure difference across the lamina cribrosa (LC) related to a low intracranial pressure (ICP). Prospective case-control study. Thirteen NTG patients (9 women; median 71 [range: 56-83] years) were recruited for investigation with the same protocol as 11 healthy volunteers (8 women; 47 [30-59] years). A larger control group (n = 51; 30 women; 68 [30-81] years) was used only for ICP comparison in supine position. ICP and intraocular pressure (IOP) were simultaneously measured in supine, sitting, and 9° head-down tilt (HDT) positions. Trans-lamina cribrosa pressure difference (TLCPD) was calculated using ICP and IOP together with geometric distances estimated from magnetic resonance imaging to adjust for hydrostatic effects. ICP, IOP, and TLCPD in different body positions. Between NTG patients and healthy volunteers, there were no differences in ICP, IOP, or TLCPD in supine, sitting, or HDT (P ≥ 0.11), except for IOP in HDT (P = 0.04). There was no correlation between visual field defect and TLCPD, IOP, or ICP and in any body position (P ≥ 0.39). Mean ICP in supine was 10.3 mmHg (SD = 2.7) in the NTG group (n = 13) and 11.3 (2.2) mmHg in the larg...Continue Reading

Citations

Oct 12, 2019·Acta Ophthalmologica·Eliška NajmanováMarkéta Haklová
Aug 12, 2018·Investigative Ophthalmology & Visual Science·Yuejiao JinMichaël J A Girard
Feb 7, 2020·PloS One·Emily S NelsonBrian C Samuels
Apr 22, 2020·Investigative Ophthalmology & Visual Science·Yuejiao JinMichaël J A Girard
Nov 11, 2019·The British Journal of Ophthalmology·David Andrew PriceAlon Harris
Apr 14, 2018·Current Neurology and Neuroscience Reports·Gauti JóhannessonChristina Lindén
Jun 20, 2019·Neurosurgery·Karina Marshall-GoebelEric M Bershad
Apr 30, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A HändelC Cursiefen
May 29, 2020·Eye·Achmed Pircher, Hanspeter E Killer
Jan 18, 2019·Experimental and Therapeutic Medicine·Alexandra TrivliEfstathios T Detorakis
Jun 20, 2020·PloS One·Allison R LoiselleNomdo M Jansonius
Dec 2, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A HändelC Cursiefen
Jul 14, 2020·Ophthalmology·Anders WåhlinAnders Eklund
Apr 21, 2021·Investigative Ophthalmology & Visual Science·Petter HolmlundAnders Eklund
Apr 30, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Zhaobin FangMing Xiao
Jun 8, 2021·European Journal of Ophthalmology·Marcelina SobczakMalwina Geniusz
Oct 3, 2021·Journal of Cellular and Molecular Medicine·Jin-Liang Yue, Shu-Feng Zheng
Nov 26, 2019·Seminars in Cell & Developmental Biology·Serena MirraJordi Garcia-Fernàndez

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