PMID: 18705610Aug 19, 2008Paper

Normal tissue dose-effect models in biological dose optimisation

Zeitschrift für medizinische Physik
Markus Alber

Abstract

Sophisticated radiotherapy techniques like intensity modulated radiotherapy with photons and protons rely on numerical dose optimisation. The evaluation of normal tissue dose distributions that deviate significantly from the common clinical routine and also the mathematical expression of desirable properties of a dose distribution is difficult. In essence, a dose evaluation model for normal tissues has to express the tissue specific volume effect. A formalism of local dose effect measures is presented, which can be applied to serial and parallel responding tissues as well as target volumes and physical dose penalties. These models allow a transparent description of the volume effect and an efficient control over the optimum dose distribution. They can be linked to normal tissue complication probability models and the equivalent uniform dose concept. In clinical applications, they provide a means to standardize normal tissue doses in the face of inevitable anatomical differences between patients and a vastly increased freedom to shape the dose, without being overly limiting like sets of dose-volume constraints.

References

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Citations

Dec 17, 2009·Radiation Oncology·Marcin SikoraMarkus Alber
May 3, 2011·Zeitschrift für medizinische Physik·Thomas DirscherlLudwig Bogner
Sep 14, 2010·Zeitschrift für medizinische Physik·Stefan SchellUwe Oelfke
Dec 8, 2009·Zeitschrift für medizinische Physik·Raphaël MoeckliFrançois Bochud
Sep 15, 2009·International Journal of Radiation Oncology, Biology, Physics·Matthias SöhnMarkus Alber
Sep 4, 2015·Radiation Oncology·Steffi KantzUte Ganswindt
May 31, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Luise A KünzelDaniela Thorwarth
Jun 9, 2009·Physics in Medicine and Biology·Ludwig BognerMark Rickhey

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