PMID: 2492272Jan 1, 1989Paper

Normal tissue reactions and complications following high-energy neutron beam therapy: I. Crude response rates

International Journal of Radiation Oncology, Biology, Physics
L CohenA Lennox

Abstract

The incidence of significant complications (fibrosis, ulceration, necrosis of bone or soft tissue or serious functional impairment) was determined in relation to neutron dosage and follow-up time for 5 anatomical sites totalling 617 patients who had survived 2 or more years following treatment. The regions studied were head and neck (268 patients), thorax (lung and esophagus, 76 patients), upper abdomen (132 patients), pelvis (prostate and bladder, 114 patients) and extremities (27 patients). Neutron doses ranged from 16 to 28 Gy. All patients were followed until death or up to 10 years after treatment. A total of 109 complications were observed yielding a crude complication rate of 18% for the whole series. Observed complication rates were 7% in the 16-20 Gy dose range, 19% between 20 and 24 Gy, and 33% in patients receiving more than 24 Gy. Probit analysis of the data indicated a median effective dose (50% complications) of 29 (+/- 0.5) Gy with an estimated standard deviation of 8 Gy. A reasonable estimate of "tolerance" may then be taken as 29 - 8 = 21 Gy. Comparing the 5 anatomical sites revealed no significant differences in estimated tolerance doses. With the available data, no effect of field-size or target volume could ...Continue Reading

References

Dec 1, 1986·International Journal of Radiation Oncology, Biology, Physics·W DuncanW J Jack
Oct 1, 1986·International Journal of Radiation Oncology, Biology, Physics·T E SchultheissD O Dixon

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Citations

May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·L CohenT K Kroc
Jul 1, 1996·International Journal of Radiation Oncology, Biology, Physics·P J ChubaJ D Forman
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R OrecchiaU Veronesi
Feb 1, 1992·The Journal of Laryngology and Otology·N StaffordR Smith
Feb 8, 2013·Medical Physics·Jay BurmeisterMichael Snyder
May 26, 1999·The British Journal of Radiology·I HenríquezA Biete
Jan 8, 2016·Journal of Orthopaedic Surgery and Research·Qiong ZouXiaoya Xu
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J M SlaterJ O Archambeau
Jan 1, 1990·Current Problems in Cancer·C D JacobsW E Fee
Aug 24, 2011·Radiation Research·Dan JiaPeter M Corry
Aug 1, 1992·The British Journal of Radiology·D J HusbandH M Warenius
Oct 12, 2007·Medical Physics·J B FarrJ D Forman
Jun 1, 1996·Clinical Otolaryngology and Allied Sciences·S AsgaraliA S Jones

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