Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype.

Nature Reviews. Cancer
Gillian C BarnettNeil G Burnet

Abstract

A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy.

References

Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J C HoriotM Bolla
Mar 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M Bentzen, M Overgaard
Oct 1, 1990·International Journal of Radiation Oncology, Biology, Physics·A AgrenI Turesson
Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·I Turesson
Jun 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·I Turesson, H D Thames
Aug 1, 1987·International Journal of Radiation Oncology, Biology, Physics·R M HartC H Park
Jul 30, 1994·International Journal of Radiation Oncology, Biology, Physics·R J CaplanJ D Cox
Apr 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·S M BentzenJ Overgaard
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics
Dec 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·N G BurnetJ H Peacock
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·L J PetersB W Brown
Jul 30, 1994·International Journal of Radiation Oncology, Biology, Physics·C Haie-MederA Gerbaulet
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·F B GearaW A Brock
Mar 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D ChassagneG Michel
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M BentzenJ Overgaard
Jan 1, 1996·Clinical Oncology : a Journal of the Royal College of Radiologists·N G BurnetJ H Peacock
Aug 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J JohansenM Overgaard
Dec 1, 1996·International Journal of Radiation Oncology, Biology, Physics·I TuressonA Odén
Jan 1, 1996·Acta Oncologica
Jan 1, 1996·Acta Oncologica·N Einhorn
May 20, 1998·International Journal of Radiation Biology·C M WestJ H Hendry
May 9, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J PeacockJ Yarnold
Sep 7, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J W Hopewell, K R Trott
Oct 6, 2000·International Journal of Radiation Oncology, Biology, Physics·S JohanssonJ Denekamp
Oct 31, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P B RogersC F Arlett
May 22, 2001·British Medical Bulletin·M FeijenD S Postma
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·C M WestR D Hunter
Mar 20, 2002·Clinical Oncology : a Journal of the Royal College of Radiologists·S E DavidsonM A Harris
Jul 4, 2002·International Journal of Radiation Oncology, Biology, Physics·Herman Suit
Jul 16, 2002·Seminars in Radiation Oncology·Eli Glatstein
Aug 15, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jeanette DicksonCatharine M L West
Aug 15, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Blanche P Alter
May 2, 2003·Nature Genetics·Nelson Freimer, Chiara Sabatti
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Ekkehard DikomeyHorst Jung
Aug 30, 2003·Trends in Cell Biology·John H J Petrini, Travis H Stracker
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael BaumannAdrian C Begg
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christian Nicolaj AndreassenJens Overgaard

❮ Previous
Next ❯

Citations

Apr 6, 2012·Wiener medizinische Wochenschrift·Edgar Selzer, Alexandra Hebar
Sep 4, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J LacombeD Azria
Dec 12, 2012·Bone Marrow Transplantation·L WangA Janin
Dec 4, 2013·Nature Reviews. Urology·Rosalind EelesZsofia Kote-Jarai
Sep 22, 2012·The Journal of Biological Chemistry·Mohammad HneinoFabien Milliat
Aug 17, 2011·Genome Research·Denis A SmirnovVivian G Cheung
Mar 1, 2010·Therapeutic Advances in Medical Oncology·Sunali MehtaCristin Print
Oct 6, 2012·Clinical Sarcoma Research·Amy Berrington de GonzalezPreetha Rajaraman
Aug 25, 2011·Genome Medicine·Catharine M West, Gillian C Barnett
Mar 13, 2012·International Journal of Medical Sciences·Rajamanickam BaskarKheng-Wei Yeoh
Apr 5, 2014·BioMed Research International·Thomas Van den BroeckFrank Claessens
Nov 5, 2013·Antioxidants & Redox Signaling·Wil L Santivasi, Fen Xia
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Kamalesh Dattaram MumbrekarSatish Rao Bola Sadashiva
May 6, 2014·Radiation and Environmental Biophysics·Jennifer J HuBrian E Lally
Jul 1, 2014·Nanomedicine·Wilfred NgwaG Mike Makrigiorgos
Nov 8, 2013·The British Journal of Radiology·M Durante
Feb 6, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan D SchoenfeldLorelei A Mucci
Dec 9, 2014·Expert Review of Anticancer Therapy·Gustavo Nader MartaJohn H Suh
May 7, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·N G BurnetUNKNOWN RAPPER Investigators
Feb 19, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Gazanfar RahmathullaRobert J Weil
Mar 6, 2012·Seminars in Radiation Oncology·Catharine M L WestBarry S Rosenstein
Dec 27, 2011·The British Journal of Oral & Maxillofacial Surgery·J S BrownS N Rogers
Jun 8, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·G C BarnettC E Coles
Jun 29, 2011·International Journal of Radiation Oncology, Biology, Physics·Andrew J LyonsRichard J Shaw
May 31, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Robert J S MurrayChristopher J Talbot
Apr 26, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E C KoB S Rosenstein
Feb 25, 2011·International Journal of Radiation Oncology, Biology, Physics·Fabienne BilliardChristine Linard
Nov 19, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cary Dehing-OberijePhilippe Lambin

❮ Previous
Next ❯

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