Normal Uptake of 11 C-Acetate in Pancreas, Liver, Spleen, and Suprarenal Gland in PET

Canadian Journal of Gastroenterology & Hepatology
Bogdan MalkowskiMichal Studniarek

Abstract

11C-Acetate is radiotracer being considered an alternative to 18F-fluorodeoxyglucose. Evaluation of 11C-acetate biodistribution in human parenchymal organs is described. 60 consecutive patients referred to 11C-acetate PET CT suspected of renal or prostate cancer relapse with negative results (no recurrent tumor) were included in the study. Acquisition from the base of skull to upper thigh was made 20 min after i.v. injection of 720 MBq of 11C-acetate. The distribution was evaluated by measuring the uptake in pancreas (uncinate process and body separately), liver, spleen, and left suprarenal gland. Clinical data of included patients showed no abnormalities in these organs. Biodistributions of 11C-acetate radiotracer were compared in different organs. Standardized uptake values of 11C-acetate were significantly higher in pancreatic parenchyma (SUV mean 6,4) than in liver (SUV mean 3,3), spleen (SUV mean 4,5), or suprarenal gland (SUV mean 2,7) tissues. No significant difference was found between pancreatic head (SUV mean 6,4) and body (SUV mean 5,9) uptake. In case of all aforementioned organs, there were no differences either between both sexes or between formerly diagnosed tumors (renal and prostate). Evaluation of 11C-acetate ...Continue Reading

References

Jun 29, 2002·European Journal of Endocrinology·Domenico RubelloBrahm Shapiro
Mar 21, 2003·Biochemical and Biophysical Research Communications·Johannes V SwinnenGuido Verhoeven
Apr 20, 2013·Current Pharmaceutical Biotechnology·Laura M Deford-WattsSteven J Kridel
May 21, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joo Hyun ORichard L Wahl
Jul 18, 2014·PET Clinics·Georgios Karanikas, Mohsen Beheshti
May 16, 2017·Digestive Diseases and Sciences·Daniel LewStephen Pandol

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Citations

Jan 29, 2019·Clinical Nuclear Medicine·Junichi TsuchiyaUkihide Tateishi

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