Normal Values of Corrected Heart-Rate Variability in 10-Second Electrocardiograms for All Ages

Frontiers in Physiology
Marten E van den BergJ A Kors

Abstract

Purpose: Heart-rate variability (HRV) measured on standard 10-s electrocardiograms (ECGs) has been associated with increased risk of cardiac and all-cause mortality, but age- and sex-dependent normal values have not been established. Since heart rate strongly affects HRV, its effect should be taken into account. We determined a comprehensive set of normal values of heart-rate corrected HRV derived from 10-s ECGs for both children and adults, covering both sexes. Methods: Five population studies in the Netherlands (Pediatric Normal ECG Study, Leiden University Einthoven Science Project, Prevention of Renal and Vascular End-stage Disease Study, Utrecht Health Project, Rotterdam Study) provided 10-s, 12-lead ECGs. ECGs were stored digitally and analyzed by well-validated analysis software. We included cardiologically healthy participants, 42% being men. Their ages ranged from 11 days to 91 years. After quality control, 13,943 ECGs were available. Heart-rate correction formulas were derived using an exponential model. Two time-domain HRV markers were analyzed: the corrected standard deviation of the normal-to-normal RR intervals (SDNNc) and corrected root mean square of successive RR-interval differences (RMSSDc). Results: There wa...Continue Reading

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Citations

Jan 5, 2019·Journal of the American Heart Association·Sander LamballaisM Arfan Ikram
Apr 29, 2019·Neuroscience Bulletin·Chunyan TaoJunbao Du
Sep 11, 2019·European Journal of Preventive Cardiology·Balewgizie S TegegneHarriëtte Riese
Nov 27, 2020·Journal of Clinical Medicine·Christiane WallerPeter Radermacher
Feb 3, 2021·Journal of the American Heart Association·Lisette M HarteveldUNKNOWN FemNAT‐CD collaborators *
Jan 3, 2021·Restorative Neurology and Neuroscience·Kyle D MeeuwsenElyse K White
Jan 11, 2021·Seminars in Cell & Developmental Biology·Annelise A Madison, Janice K Kiecolt-Glaser
Jun 8, 2021·Frontiers in Cardiovascular Medicine·Paulina Lubocka, Robert Sabiniewicz
Jul 30, 2021·Health Science Reports·Reiner BuchhornChristian Willaschek
Oct 9, 2021·PloS One·Leopoldo GaravagliaIsabel M Irurzun
Oct 29, 2021·PloS One·Maartje B A MolYori Gidron

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Methods Mentioned

BETA
coronary bypass

Software Mentioned

gamlss
Modular ECG Analysis System ( MEANS )
MEANS
package gamlss
R

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