Normal volume of distribution of tobramycin in a mother and daughter with a CFTR splice mutation (1717 - 1G --> A)

Pediatric Pulmonology
Dawn SimonDrucy Borowitz

Abstract

A mother and daughter pair with CF who shared a splice mutation (1717 - 1G --> A) had a normal volume of distribution of tobramycin. The literature on tobramycin pharmacokinetics, which was published before the genetic defect was identified, is discussed. The authors speculate on the role of CFTR in the distribution of aminoglycosides and recommend that CFTR mutations should be clarified in all future studies of tobramycin pharmacokinetics in patients with CF.

References

Dec 1, 1983·The Journal of Pediatrics·N E MacDonaldK R Powell
Feb 1, 1982·The Journal of Pediatrics·G L KearnsJ T Wilson
Feb 1, 1982·The Journal of Pediatrics·H B KellyS Murphy
May 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·D Borowitz, K Conboy
May 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·M AzcueP B Pencharz
Dec 1, 1996·Journal of Medical Genetics·R PadoanL Cremonesi

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