Normalization of depressed heart function in rats by ribose

Science
H G Zimmer

Abstract

Severe constriction of the abdominal aorta and simultaneous injection of isoproterenol in rats induced depression in heart function and reductions in cardiac adenosine triphosphate and total adenine nucleotides. When ribose was continuously infused for 24 hours, biosynthesis of cardiac adenine nucleotides was stimulated to such an extent that the reductions in adenosine triphosphate and total adenine nucleotides were prevented and left ventricular hemodynamic parameters were normal. These results support the hypothesis that adenosine triphosphate is primarily responsible for depression in myocardial contractility and that ribose is cardioprotective through its pronounced effects on adenine nucleotide metabolism in heart muscle.

References

Nov 1, 1979·The American Journal of Physiology·R J WeigelC L Prosser
Sep 29, 1978·Pflügers Archiv : European journal of physiology·H G Zimmer, E Gerlach
Oct 1, 1974·Circulation Research·H G Zimmer, E Gerlach
Jan 1, 1972·Pflügers Archiv : European journal of physiology·H G ZimmerE Gerlach
Oct 1, 1972·Journal of Molecular and Cellular Cardiology·V T WiedmeierR M Berne
Sep 1, 1971·American Heart Journal·R A DeWallP Kezdi
Mar 1, 1970·Journal of Molecular and Cellular Cardiology·W KüblerH J Bretschneider
Jan 1, 1970·Pflügers Archiv : European journal of physiology·W IsselhardW Mäurer
Apr 1, 1969·The American Journal of Physiology·J W CrowellE E Smith
Apr 1, 1980·Journal of Molecular and Cellular Cardiology·H G ZimmerH Koschine
Aug 1, 1982·Journal of Molecular and Cellular Cardiology·H G Zimmer
Nov 1, 1981·Circulation·D S BlumenthalL C Becker
Jan 1, 1962·The Journal of Clinical Investigation·W L GLEASON, E BRAUNWALD
Feb 1, 1963·The American Journal of Physiology·R M BERNE
Apr 1, 1965·Annals of Internal Medicine·J B WYNGAARDENE N METZ

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Citations

Oct 1, 1991·Cardiovascular Drugs and Therapy·M B Forman, C E Velasco
Sep 1, 1991·Pflügers Archiv : European journal of physiology·T P Geisbuhler, M J Rovetto
Jun 7, 1995·Molecular and Cellular Biochemistry·H G ZimmerC K Kolbeck-Rühmkorff
Mar 1, 1996·Journal of the Neurological Sciences·I C SteeleD P Nicholls
Jul 1, 1987·Journal of Molecular and Cellular Cardiology·H G ZimmerG Marschner
Feb 28, 2003·Medical Hypotheses·D F PaulyJ A St Cyr
Dec 2, 1992·Molecular and Cellular Biochemistry·M J de GrootG J van der Vusse
Nov 13, 2004·Pharmacotherapy·Benjamin Gebhart, James A Jorgenson
Jun 16, 2009·Progress in Cardiovascular Nursing·Susan WagnerJohn A St Cyr
Oct 20, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·James C GriffithsJohn St Cyr
Oct 3, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·James C GriffithsJohn St Cyr
Feb 12, 2011·Therapeutic Advances in Cardiovascular Disease·Linda M ShecterleJohn A St Cyr
Jan 11, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·D F Pauly, C J Pepine
Mar 17, 2020·Nutrition Research Reviews·Arrigo F G CiceroUNKNOWN International Lipid Expert Panel
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Regis R LambertsGer J M Stienen
Jan 1, 1988·Basic Research in Cardiology·H G ZimmerA E Varekamp
Jun 17, 2020·Neuroscience Bulletin·Bruno G Frenguelli, Nicholas Dale
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·G W GoodwinH Taegtmeyer
Nov 1, 1987·The American Journal of Physiology·T P GeisbuhlerM J Rovetto

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