Normalization of doxorubicin release from graphene oxide: New approach for optimization of effective parameters on drug loading

Biotechnology and Applied Biochemistry
Mohadeseh HashemiLobat Tayebi

Abstract

Graphene oxide (GO) has been recently introduced as a suitable anticancer drug carrier, which could be loaded with doxorubicin (DOX) as a general chemotherapy agent. Herein, the attempts were made to optimize the effective parameters on both loading and release of DOX on GO. GO and GO-DOX were characterized using transition electron microscopy , zeta potential, Raman spectroscopy, UV-visible spectroscopy, and Fourier transform infrared spectroscopy. In addition, loading and releasing behaviors of DOX on GO were studied in terms of different temperature and pH values. The primary optimized values of pH and temperature for best-loaded amount of DOX were 8.9 and 309 K, respectively. Moreover, we found that the smallest amount of released DOX, in pH of cancer microenvironment (5.4), occurs when DOX had been previously loaded in pH 7.8 and 310 K. Although the highest amount of loaded DOX was in basic pH, the results of efficient release of DOX from the GO-DOX complex and also cellular toxicity assay revealed that the best pH for loading of DOX on GO was 7.8. Therefore, in addition to optimization of parameters for efficient loading of DOX on GO, this study suggested that normalization of a released drug compared with the amount of a...Continue Reading

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Citations

Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gaurav ChauhanAmit K Goyal
Aug 30, 2018·Journal of Biomedical Optics·Mohadeseh HashemiThomas E Milner
Aug 25, 2018·Journal of Biomedical Optics·Carole K HayakawaVasan Venugopalan
Jun 4, 2019·Medicina·Alexa CroitoruEcaterina Andronescu
Feb 7, 2019·Engineering in Life Sciences·Zahra Akbari JonousMeisam Omidi
Aug 6, 2020·Nanomaterials·Erica QuagliariniGiulio Caracciolo
May 24, 2019·Biotechnology and Applied Biochemistry·Hanieh MalekimusaviNaghmeh Faal Hamedani
Feb 20, 2020·Carbohydrate Polymers·Samira MalmirMona Navaee
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Amany M SawyAhmed S G Khalil
Nov 8, 2017·Acta Biomaterialia·Mohadeseh HashemiThomas E Milner

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