PMID: 3773433Oct 1, 1986Paper

'Normalization' of germfree mice after direct and indirect contact with mice having a 'normal' intestinal microflora

Laboratory Animals
J P KoopmanF Nagengast

Abstract

Germfree mice were associated via direct and indirect contact with a 'normal' microflora by placing 'normal' mice in an isolator with germfree mice. Relative caecal weights, the ratio of secondary to primary bile acids, the presence of filamentous segmented bacteria in the small intestine and faecal beta-aspartylglycine were normal 5 days after direct contact and 15 days after indirect contact. Enterobacteriaceae were demonstrated by the third day after direct contact and the fourth day after indirect contact. Volatile and non-volatile fatty acids in the caecal contents were variable and appeared to be unrelated to the 'normalization' process of germfree mice after association with a microflora.

Citations

Jan 1, 1989·The Veterinary Quarterly·J P KoopmanF Nagengast
Jan 5, 2012·Journal of Visualized Experiments : JoVE·Peter Heath, Sandrine Paule Claus
Nov 3, 2010·Current Opinion in Microbiology·Bärbel Stecher, Wolf-Dietrich Hardt
Jun 21, 2016·Cell Metabolism·Annika WahlströmFredrik Bäckhed
Jun 1, 1992·FEMS Microbiology Reviews·H L KlaasenA C Beynen

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