PMID: 8967885Dec 1, 1995Paper

Normalization of hematocrit with recombinant human erythropoietin in chronic hemodialysis patients does not fully improve their exercise tolerance abilities

Artificial Organs
M SuzukiY Hirasawa

Abstract

In the recombinant human erythropoietin (rHuEPO) treatment of renal anemia, the target level has widely been accepted as approximately 30% of hematocrit (Hct) which means only partial improvement of the anemia. We tried to maintain 1 female and 9 male patients within a normal Hct and to estimate their exercise tolerance abilities. During the study, no serious complications were experienced. Their maximal oxygen uptake (VO2max), evaluated for 1-6 months after reaching the desired Hct of 35-40% with rHuEPO, was 30.7 +/- 2.4 ml of O2/kg/min. These results were significantly higher than those of the control groups whose Hct levels were maintained at around 30%. Although 1 female and 2 male patients were considered to be within the normal exercise tolerance abilities, the others showed lower values in comparison with the Japanese age- and sex-matched values. Thus, it is not always possible to regain full exercise tolerance abilities even after restoring a normal Hct. Unknown factors besides anemia impairing their exercise tolerance abilities might exist in chronic dialysis patients.

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Citations

Sep 16, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rian M EijsermansCock H Schröder
Jan 14, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Emma L ClappAlice C Smith
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Oct 9, 2003·Kidney International. Supplement·Donna M Mancini, Chandra Kunavarapu
Dec 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Farhan J BukhariHamid M Said
Dec 14, 1999·Current Opinion in Nephrology and Hypertension·S T Murphy, P S Parfrey
Mar 17, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Aalia AkberKirsten L Johansen
Jul 29, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George C KosmadakisJohn Feehally
May 2, 2002·Kidney International. Supplement·Juan M López Gómez, Fernando Carrera
Jun 7, 2007·The International Journal of Artificial Organs·G C Kosmadakis, N Zerefos
Sep 4, 2019·Advances in Chronic Kidney Disease·Jonathan Bazeley, Jay B Wish
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·J Z MaA J Collins
Mar 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation

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