Normalization of mucosal tumor necrosis factor-α: A new criterion for discontinuing infliximab therapy in ulcerative colitis

Cytokine
Trine OlsenJon Florholmen

Abstract

Biological agents such as anti-tumor necrosis factor (TNF) induce remission in ulcerative colitis. There is however no consensus regarding the discontinuation of this treatment. The aim of this study is to assess whether clinical parameters and mucosal cytokine mRNAs in healed colonic mucosa can predict long-term remission in ulcerative colitis following discontinuation of infliximab (IFX) therapy. The prospective Tromsø Inflammatory Bowel Disease (IBD) Study is based on an intensified induction treatment algorithm with IFX to achieve disease remission. Following clinical and endoscopic remission, IFX treatment was discontinued, and follow-up until relapse was performed. Patients who achieved clinical and endoscopic remission following an induction course of IFX were included. Expression levels of TNF alpha (TNF), interferon gamma (IFNG), interleukin (IL) 6 (IL6), IL17A, IL23, and transforming growth factor beta (TGFB) were quantified by real-time PCR in mucosal biopsies obtained at colonoscopy. Remission was defined as Ulcerative Colitis Disease Activity Index (UCDAI) below 3, and an endoscopic sub-score of 0-1. Relapse was defined as UCDAI score >3 and endoscopic sub-score >1. Mucosal cytokine transcript levels from 20 non-IB...Continue Reading

References

Dec 13, 2005·The New England Journal of Medicine·Paul RutgeertsJean Frédéric Colombel
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Trine OlsenJon Florholmen
Dec 23, 2008·Scandinavian Journal of Gastroenterology·Inger Camilla SolbergUNKNOWN IBSEN Study Group
Apr 3, 2009·Inflammatory Bowel Diseases·Fabian SchnitzlerPaul Rutgeerts
Oct 13, 2009·Gastroenterology·Filip BaertUNKNOWN North-Holland Gut Club
Sep 24, 2011·Journal of Crohn's & Colitis·Marco DapernoUNKNOWN Scientific Committee of the European Crohn's and Colitis Organization
Sep 29, 2011·Gastroenterology·Edouard LouisUNKNOWN Groupe D'etudes Thérapeutiques Des Affections Inflammatoires Digestives
Nov 2, 2011·Scandinavian Journal of Gastroenterology·Jon Florholmen, Walter Fries
Apr 18, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laura RosenbergAlan C Moss
Jun 19, 2013·Gastroenterology·William J SandbornUNKNOWN PURSUIT-Maintenance Study Group
Aug 24, 2013·The New England Journal of Medicine·Brian G FeaganUNKNOWN GEMINI 1 Study Group
Jun 25, 2014·Alimentary Pharmacology & Therapeutics·B Pariente, D Laharie
Dec 20, 2014·Scandinavian Journal of Gastroenterology·Jon Florholmen

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Citations

Oct 18, 2016·European Journal of Gastroenterology & Hepatology·Kay-Martin JohnsenJon Florholmen
Oct 11, 2017·Journal of Clinical Gastroenterology·Shomron Ben-HorinMinhu Chen
Aug 31, 2018·Therapeutic Advances in Gastroenterology·Aleksandar AcovicVladislav Volarevic
Jun 18, 2020·Pharmaceutics·Bahez GarebJos G W Kosterink
Mar 19, 2021·Clinical and Translational Gastroenterology·Francisco BravoUNKNOWN SATICC (Sensitivity to Anti-TNF Inhibition in Crohn's disease and ulcerative Colitis) study group

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