Normalization of serum rapid plasma reagin titer predicts normalization of cerebrospinal fluid and clinical abnormalities after treatment of neurosyphilis.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
C M MarraS A Lukehart

Abstract

Success of neurosyphilis treatment is defined by normalization of cerebrospinal fluid (CSF) and clinical abnormalities. The goal of this study was to determine whether normalization of serum rapid plasma reagin (RPR) titer could accurately predict treatment success. One hundred ten patients who were enrolled in a longitudinal study of CSF abnormalities in syphilis had asymptomatic syphilitic meningitis, symptomatic syphilitic meningitis, or syphilitic eye disease and were treated for neurosyphilis. At 4, 7, and 13 months after treatment, serum RPR titer and CSF and clinical abnormalities were analyzed for normalization. Odds ratios for normalization of each CSF and clinical abnormality when serum RPR titer had normalized and the positive predictive value of normalization of serum RPR titer for normalization of CSF and clinical abnormalities were determined. Serum RPR titer had normalized in 63 patients (57%) by 4 months after treatment, in 94 (85%) by 7 months, and in 97 (88%) by 13 months. Except for CSF protein concentration, normalization of serum RPR titer predicted normalization of other CSF and clinical abnormalities in >80% of patients at 4 months, >85% at 7 months, and >90% at 13 months. The odds of normalization of CSF...Continue Reading

References

Aug 1, 1985·Antimicrobial Agents and Chemotherapy·C W YimF T Fitzgerald
Feb 1, 1972·JAMA : the Journal of the American Medical Association·H HooshmandS W Kopf
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C M MarraE W Hook
Jan 28, 2004·The Journal of Infectious Diseases·Christina M MarraScott H Barnett
Mar 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christina M MarraSheila A Lukehart
Nov 19, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·M Timmermans, J Carr

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Citations

Feb 26, 2009·Current Infectious Disease Reports·Christina M Marra
Feb 11, 2011·Current Infectious Disease Reports·Khalil G Ghanem
Dec 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly A Workowski, Stuart M Berman
Dec 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Khalil G Ghanem, Kimberly A Workowski
Sep 18, 2010·JAAPA : Official Journal of the American Academy of Physician Assistants·Kishore KuppasaniAlluru S Reddi
May 18, 2013·Sexually Transmitted Diseases·Seong Yeon ParkDo Yeun Kim
Oct 4, 2013·Journal of Clinical Microbiology·Jeannot DumaresqMichel Roger
Oct 5, 2013·Annales de dermatologie et de vénéréologie·M LerouxA Cheret
Nov 29, 2011·Médecine et maladies infectieuses·K C PsomasV Le Moing
Nov 17, 2015·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Tadashi MaedaYoshihisa Urita
Nov 3, 2015·Internal Medicine·Hideharu HagiyaFumio Otsuka
Jul 16, 2010·CNS Neuroscience & Therapeutics·Khalil G Ghanem
Feb 25, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·X LuoY Ning
Jun 16, 2015·Case Reports in Infectious Diseases·Shagufta Ahsan, Joesph Burrascano
Nov 13, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan Tuddenham, Khalil G Ghanem
Apr 6, 2016·Sexually Transmitted Infections·Motoyuki TsuboiHiroyuki Gatanaga
Aug 12, 2016·International Journal of STD & AIDS·Riddhi PatiraJijo J Wang
Apr 6, 2017·Early Intervention in Psychiatry·Ben ChenNing Yuping
Oct 22, 2013·Arquivos de neuro-psiquiatria·Luís dos Ramos MachadoLiliana Scaff Vianna
Jan 13, 2017·Medicine·Mohaned ShilaihUNKNOWN and the Swiss HIV Cohort Study
Dec 21, 2016·Lancet·Edward W Hook
Jan 2, 2016·International Journal of STD & AIDS·M KingstonAnn Sullivan
Nov 28, 2014·Clinical and Vaccine Immunology : CVI·Muhammad G Morshed, Ameeta E Singh
Aug 31, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Kelly Meehan, Julie Rodman
Mar 9, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·El Hadji Makhtar BaJérémie Pariente
Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shelia B DunawayChristina M Marra
Dec 4, 2019·Current Opinion in Infectious Diseases·Ameeta E Singh
Feb 27, 2020·The New England Journal of Medicine·Khalil G GhanemPeter A Rice
Mar 13, 2020·Ocular Immunology and Inflammation·Ilaria TestiVishali Gupta
Apr 22, 2015·Sexual Health·Emily L Ho, Serena S Spudich
Nov 13, 2015·Sexually Transmitted Diseases·Julia C DombrowskiMatthew R Golden
Apr 13, 2017·Case Reports in Medicine·Sunit ToliaAna Capatina-Rata
Apr 19, 2018·Case Reports in Neurological Medicine·Kalimullah JanShekhawat Ravindra Singh
Jan 1, 2012·The American Journal of Case Reports·Shaffer R S MokDavid L Shklar
Sep 15, 2016·Expert Review of Anti-infective Therapy·Chelsea P Roberts, Jeffrey D Klausner
Oct 3, 2019·The New England Journal of Medicine·Allan H Ropper
Feb 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura A S QuilterElizabeth Torrone
Aug 22, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M Musher
Oct 24, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M JanierR Patel
Oct 18, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Waki ImotoHiroshi Kakeya
Mar 18, 2021·Epidemiologia E Serviços De Saúde : Revista Do Sistema Unico De Saúde Do Brasil·Francisca Lidiane Sampaio FreitasAngélica Espinosa Miranda

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