Normative Cognitive Decline in Old Age.

Annals of Neurology
Robert S WilsonPatricia A Boyle

Abstract

To characterize trajectories of normative cognitive aging. Older persons without dementia at study enrollment (n = 1,010) had annual cognitive testing for up to 24 years (mean = 9.9 years, standard deviation = 5.0), died, and underwent a neuropathologic examination to quantify 9 postmortem markers of common neurodegenerative and cerebrovascular conditions. To accommodate the heterogeneity in cognitive trajectories, we used functional mixed effects models, which allow individuals to have different patterns of cognitive decline under a unified model structure. In a functional mixed effects model, postmortem markers (Alzheimer disease pathology, Lewy bodies, transactive response DNA-binding protein 43 pathology, hippocampal sclerosis, atherosclerosis, gross infarcts) were associated with global cognitive decline. Residual global cognitive decline after adjustment for neuropathologic burden was weakly related to age at death; it occurred in only about one-third of participants, mostly proximate to death. Results were comparable after eliminating the initial cognitive assessments to minimize retest learning or controlling for frailty proximate to death. Analyses were also conducted with composite measures of episodic memory and perc...Continue Reading

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Citations

Apr 3, 2020·Annals of Neurology·Rachel Buckley, Alvaro Pascual-Leone
Feb 10, 2021·Neurochemical Research·Marloes VerkerkeJinte Middeldorp
Feb 18, 2021·Journal of Neurology·Hannah KösterRüdiger J Seitz
Nov 14, 2020·Journal of Alzheimer's Disease : JAD·Shahram OveisgharanZoe Arvanitakis
Jun 2, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Patricia A BoyleDavid A Bennett
May 21, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jie ZhangYunfeng Zou
Jun 1, 2021·Journal of Alzheimer's Disease : JAD·Shama D KaranthErin L Abner

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