Normative Data for Thyroid Stimulating Hormone for Screening of Congenital Hypothyroidism

Indian Journal of Pediatrics
ICMR Task Force on Inherited Metabolic Disorders

Abstract

To generate normative data for thyroid stimulating hormone (TSH) levels in heel prick samples collected from newborns from 24 h to 7 d of age. Five regional laboratories were designated as the testing laboratories. Dried blood spots (DBS) from babies (> or = 34 wk of gestation) were collected by heel prick at least after 24 h and within seven days after birth. TSH estimation was done using time resolved fluoroimmunoassay. Values above 20mIU/L were labelled as presumptive positive. Hour interval specific normative data was categorized at 6 h intervals. Another category placed was division into 24-72 h category, 73-96 h and 99-168 h. Percentile charts were calculated across these specified intervals. Samples analysed were 104,006 collected cumulatively from the 5 centers. Of the total samples analysed for TSH, 92.8% had values less than 5 mIU/l. When TSH values were interpreted with respect to time, a steady decrease with time was observed. Of the babies' samples, 48,839 were collected between 24 and 48 h, 23,983 between 49 to 72 h and 30,883 were collected after 72 h. The mean TSH concentration demonstrated a steady decline from 24 h to 168 h. It is apparent that 10 mIU/l is the 97.5th percentile value even when corrected for ge...Continue Reading

References

Jun 3, 2006·Pediatrics·Susan R RoseSurendra K Varma
Feb 28, 2008·Thyroid : Official Journal of the American Thyroid Association·Julie HerbstmanLynn R Goldman
Aug 20, 2009·Hormone Research·Murthy KoradaTim Cheetham
Apr 5, 2014·Indian Journal of Endocrinology and Metabolism·Sara SheikhbahaeiFatemeh Nayeri
May 7, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Umesh KapilShubhra Pande
Sep 18, 2014·Indian Pediatrics·Vignesh GopalakrishnanVijayalakshmi Bhatia
Oct 10, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·E Y ImamogluF Ovali
Dec 17, 2015·Hormone Research in Pædiatrics·Iroro E YarhereNwadiuto A Akani

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Citations

Jul 19, 2019·PloS One·Ernesto Cortés-CastellMaría Mercedes Rizo-Baeza
Mar 25, 2020·International Journal of Environmental Research and Public Health·John FriesenPeter F Pelz
Mar 17, 2018·Indian Journal of Pediatrics·UNKNOWN ICMR Task Force on Inherited Metabolic Disorders

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