Normative data of contact heat evoked potentials from the lower extremities

Scientific Reports
Jan RosnerM Hubli

Abstract

Contact heat evoked potentials (CHEPs) have become an acknowledged research tool in the assessment of the integrity of the nociceptive system and gained importance in the diagnostic work-up of patients with suspected small fiber neuropathy. For the latter, normative values for CHEP amplitude and latency are indispensable for a clinically meaningful interpretation of the results gathered in patients. To this end, CHEPs were recorded in 100 healthy subjects over a wide age range (20-80 years) and from three different dermatomes of the lower extremities (L2, L5, and S2). A normal baseline (35-52 °C) and increased baseline stimulation (42-52 °C) were applied. Statistical analysis revealed significant effects of stimulation site, stimulation intensity, and sex on CHEP parameters (N2 latency, N2P2 amplitude, and NRS). Significant positive correlations of body height with N2 latency, and pain ratings with N2P2 amplitudes were observed. This is the first time that normative values have been obtained from multiple dermatomes of the lower extremities. The present dataset will facilitate the clinical application of CHEPs in the neurophysiological diagnosis of small fiber neuropathy and by discerning pathological findings help establish a ...Continue Reading

References

May 1, 1993·Electroencephalography and Clinical Neurophysiology·A BeydounK L Casey
Jan 14, 1998·Neuroreport·L García-LarreaF Mauguière
Aug 10, 2000·Italian Journal of Neurological Sciences·G Lauria
Dec 19, 2000·Neuroscience and Biobehavioral Reviews·L Gagliese, R Melzack
Jul 19, 2001·Clinics in Geriatric Medicine·S J Gibson, R D Helme
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Stuart W G DerbyshireAnthony K P Jones
Mar 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A TruiniG Cruccu
Jan 1, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Chi-Chao ChaoSung-Tsang Hsieh
Feb 12, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Susanne WydenkellerPascal Halder
Jun 6, 2008·Brain : a Journal of Neurology·Grazia DevigiliGiuseppe Lauria
Jun 19, 2008·Pain·Pedro SchestatskyJosep Valls-Solé
Oct 8, 2008·Nature Clinical Practice. Neurology·Stephan A Botez, David N Herrmann
Sep 25, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Markus QuanteMichael Hauck
Oct 4, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J L K KramerJ D Steeves
Feb 15, 2012·The Journal of Spinal Cord Medicine·Steven C KirshblumWilliam Waring
Feb 23, 2012·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·John L K KramerJohn Steeves
Jun 5, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jenny S HaefeliArmin E P Curt
Sep 27, 2014·Muscle & Nerve·Vera LagerburgIngemar S J Merkies
Feb 24, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A UlrichA Curt
Feb 24, 2015·Neuroscience Letters·Ingemar S J MerkiesGiuseppe Lauria
Feb 14, 2016·Muscle & Nerve·Amanda Cy Chan, Einar P Wilder-Smith
Mar 7, 2017·Journal of Neurotrauma·Catherine R JutzelerArmin Curt
Oct 17, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P HüllemannR Baron
Feb 8, 2018·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J RosnerC R Jutzeler

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Citations

Dec 22, 2020·Frontiers in Human Neuroscience·Malte AndersCarmen Walter
Jun 17, 2021·Human Brain Mapping·Vincent HuynhLars Michels

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Methods Mentioned

BETA
biopsies

Clinical Trials Mentioned

NCT02138344

Software Mentioned

SPSS
LabView
R

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