Normative Peak Cardiopulmonary Exercise Test Responses in Canadian Adults Aged ≥40 Years.

Chest
Hayley LewthwaiteCanCOLD Collaborative Research Group and the Canadian Respiratory Research Network

Abstract

Up-to-date normative reference sets for cardiopulmonary exercise testing (CPET) are important to aid in the accurate interpretation of CPET in clinical or research settings. This study aimed to (1) develop and externally validate a contemporary reference set for peak CPET responses in Canadian adults identified with population-based sampling; and (2) evaluate previously recommended reference equations for predicting peak CPET responses. Participants were healthy adults who were ≥40 years old from the Canadian Cohort Obstructive Lung Disease who completed an incremental cycle CPET. Prediction models for peak CPET responses were estimated from readily available participant characteristics (age, sex, height, body mass) with the use of quantile regression. External validation was performed with a second convenience sample of healthy adults. Peak CPET parameters that were measured and predicted in the validation cohort were assessed for equivalence (two one-sided tests of equivalence for paired-samples and level of agreement (Bland-Altman analyses). Two one-sided tests of equivalence for paired samples assessed differences between responses in the derivation cohort using previously recommended reference equations. Normative referenc...Continue Reading

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Citations

Jan 27, 2021·Respiratory Physiology & Neurobiology·Hayley LewthwaiteDennis Jensen
Feb 11, 2021·Chest·Hayley Lewthwaite, Dennis Jensen
Nov 21, 2020·Chest·Hayley LewthwaiteUNKNOWN Canadian Respiratory Research Network
Apr 9, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Devin B PhillipsUNKNOWN Canadian Respiratory Research Network (CRRN)
Apr 20, 2021·Annals of the American Thoracic Society·Sara J AbdallahJuthaporn Cowan
Jun 9, 2021·Chest·Hayley Lewthwaite, Dennis Jensen
Jun 9, 2021·Chest·Douglas C Johnson
Oct 15, 2021·Medicine and Science in Sports and Exercise·Devin B PhillipsUNKNOWN Canadian Respiratory Research Network

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