Normobaric hyperoxia delays and attenuates early nitric oxide production in focal cerebral ischemic rats.

Brain Research
Zhongrui YuanKe Jian Liu

Abstract

Overproduction of neuronal nitric oxide synthase (nNOS)-derived NO is detrimental during cerebral ischemia. Normobaric hyperoxia (NBO) has been shown to be neuroprotective, extending the therapeutic time window for ischemic stroke, but the mechanism is not fully understood. In the present study, using a rat model of ischemic stroke, we investigated the effect of early NBO treatment on neuronal NO production. Male Sprague-Dawley rats were given normoxia (30% O(2)) or NBO (95% O(2)) during 10, 30, 60 or 90min filament occlusion of the middle cerebral artery. NO(x)(-) (nitrite plus nitrate) and 3-nitrotyrosine were measured in the ischemic cortex. Ischemia caused a rapid increase in the production of NO(x)(-), with a peak at 10min after ischemia onset, then gradually declining to the baseline level at 60min. NBO treatment delayed the NO(x)(-) production peak to 30min and attenuated the total amount of NO(x)(-). Ischemia also increased 3-nitrotyrosine formation, which was significantly reduced by NBO treatment. Inhibition of nNOS by pre-treatment with 7-nitroindazole had similar effect as NBO treatment on NO(x)(-) and 3-nitrotyrosine production, and when combined with NBO, no further reduction in NO production was observed. Further...Continue Reading

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Citations

Apr 7, 2011·Current Opinion in Pediatrics·Joshua D Koch, Steven G Kernie
Jan 10, 2013·Medical Gas Research·Zhifeng QiKe Jian Liu
Jan 11, 2014·Progress in Neurobiology·Fan ChenXunming Ji
Jul 28, 2016·Brain and Behavior·Pavel RodriguezTimothy Q Duong
Mar 1, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julien Vincent BrugniauxPhilip N Ainslie
Aug 10, 2017·Frontiers in Neuroscience·Oleg G DeryaginVladimir B Koshelev
Mar 14, 2017·Brain Injury : [BI]·Ivana HegedušInes Drenjančević

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