Normobaric hyperoxia inhibits the progression of lung cancer by inducing apoptosis

Experimental Biology and Medicine
Sei Won KimSang Haak Lee

Abstract

Hypoxia is a critical characteristic of solid tumors with respect to cancer cell survival, angiogenesis, and metastasis. Hyperoxic treatment has been attempted to reverse hypoxia by enhancing the amount of dissolved oxygen in the plasma. In this study, we evaluated the effects of normobaric hyperoxia on the progression of lung cancer to determine whether oxygen toxicity can be used in cancer therapy. Following a tail vein injection of the Lewis lung carcinoma cells, C57BL/6J mice were exposed to a 24-h normobaric hyperoxia/normoxia cycle for two weeks. In addition, A549 lung cancer cells were incubated in a normobaric hyperoxia chamber for a 24-h period. As a result, the size and number of tumors in the lung decreased significantly with exposure to normobaric hyperoxia in the mouse model. Cell viability, colony-forming ability, migration, and invasion all decreased significantly in A549 cells exposed to normobaric hyperoxia and the normal control group exposed to normobaric hyperoxia showed no significant damage. Oxidative stress was more prominent with exposure to normobaric hyperoxia in cancer cells. A549 cells exposed to normobaric hyperoxia showed a significantly higher cell apoptosis ratio compared with A549 cells without ...Continue Reading

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Citations

Aug 30, 2019·Current Opinion in Anaesthesiology·Lothar A SchwarteStephan A Loer
Apr 25, 2020·Experimental Biology and Medicine·Sei W KimSang H Lee
Feb 2, 2021·Langenbeck's Archives of Surgery·Jadie PlückerMarkus A Weigand

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Methods Mentioned

BETA
bronchoalveolar lavage
motility assay
PCR
electrophoresis
X-ray
ELISA
MDA

Software Mentioned

[UNK] Cell Analyzer
GraphPad Prism

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