Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia

Brain : a Journal of Neurology
Sohail EjazJean-Claude Baron

Abstract

'True' transient ischaemic attacks are characterized not only clinically, but also radiologically by a lack of corresponding changes on magnetic resonance imaging. During a transient ischaemic attack it is assumed that the affected tissue is penumbral but rescued by early spontaneous reperfusion. There is, however, evidence from rodent studies that even brief focal ischaemia not resulting in tissue infarction can cause extensive selective neuronal loss associated with long-lasting sensorimotor impairment but normal magnetic resonance imaging. Selective neuronal loss might therefore contribute to the increasingly recognized cognitive impairment occurring in patients with transient ischaemic attacks. It is therefore relevant to consider treatments to reduce brain damage occurring with transient ischaemic attacks. As penumbral neurons are threatened by markedly constrained oxygen delivery, improving the latter by increasing arterial O2 content would seem logical. Despite only small increases in arterial O2 content, normobaric oxygen therapy experimentally induces significant increases in penumbral O2 pressure and by such may maintain the penumbra alive until reperfusion. Nevertheless, the effects of normobaric oxygen therapy on in...Continue Reading

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Citations

Jul 15, 2016·Brain : a Journal of Neurology·Laurent ChazalvielJacques H Abraini
May 22, 2016·Cephalalgia : an International Journal of Headache·Aneesh B SinghalMehmet A Topcuoglu
Sep 6, 2017·Expert Review of Neurotherapeutics·Sven PoliFlorian Härtig
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May 2, 2018·Stroke; a Journal of Cerebral Circulation·Jing LanXunming Ji
Feb 23, 2020·Frontiers in Neurology·Zhiying ChenRan Meng
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Dec 4, 2020·Neural Regeneration Research·Zhe ChengYu-Chuan Ding
Jan 8, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Zhe ChengYuchuan Ding
Feb 27, 2021·Cephalalgia : an International Journal of Headache·Rushil ShahNauman Tariq
Apr 4, 2021·Brain Sciences·Tiziana CiarambinoMauro Giordano
May 4, 2021·Brain Communications·Vanessa Di CataldoEmmanuelle Canet-Soulas
Jul 10, 2021·CNS Neuroscience & Therapeutics·Jia-Yue DingRan Meng

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