Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke

Neurology
Aneesh B SinghalEng H Lo

Abstract

Hyperbaric oxygen therapy is considered an important stroke treatment strategy. To determine whether normobaric oxygen is neuroprotective, and, if so, what the therapeutic time window is. Experiment 1-Serial diffusion- and perfusion-weighted MRI (DWI and PWI) was performed after middle cerebral artery filament occlusion (MCAO) in rats randomized to FiO(2) 30% (normoxia) or FiO(2) 100% (hyperoxia). Experiment 2-48-hour lesion volumes were analyzed in rats subjected to 2-hour MCAO and randomized to normoxia or hyperoxia starting 15, 30, or 45 minutes after MCAO and ending 15 minutes after reperfusion. Experiment 1-Lesion apparent diffusion coefficient (ADC) values were persistently low in normoxic animals. In hyperoxia-treated rats, ADC values in cortical border zones showed progressive recovery from 66 +/- 3% of contralateral before hyperoxia, to 104 +/- 20% at approximately 2 hours. Striatal ADC values showed early but ill-sustained improvement. ADC lesion volumes increased progressively in the normoxia group. In the hyperoxia group, ADC lesion volumes tended to decrease after starting hyperoxia; however, lesions later increased in size, and 2-hour lesion volumes were not significantly different from baseline. PWI showed stable...Continue Reading

Associated Clinical Trials

Dec 22, 2006·Aneesh B. Singhal, MD, Aneesh B. Singhal, MD

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