Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Myriam BernaudinPascale Schumann-Bard

Abstract

Tolerance to cerebral ischemia is achieved by preconditioning sublethal stresses, such as ischemia or hypoxia, paradigms in which the decrease of O2 availability may constitute an early signal inducing tolerance. In accordance with this concept, this study shows that hypoxia induces tolerance against focal permanent ischemia in adult mice. Normobaric hypoxia (8% O2 of 1-hour, 3-hour, or 6-hour duration), performed 24 hours before ischemia, reduces infarct volume by approximately 30% when compared with controls. To elucidate the mechanisms underlying this neuroprotection, the authors investigated the effects of preconditioning on cerebral expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes, erythropoietin and vascular endothelial growth factor (VEGF). Hypoxia, whatever its duration (1 hour, 3 hours, 6 hours), rapidly increases the nuclear content of HIF-1alpha as well as the mRNA levels of erythropoietin and VEGF. Furthermore, erythropoietin and VEGF are upregulated at the protein level 24 hours after 6 hours of hypoxia. The authors' findings show that (1) hypoxia elicits a delayed, short-lasting (<72 hours) tolerance to focal permanent ischemia in the adult mouse brain; (2) HIF-1 target genes could c...Continue Reading

References

Aug 1, 1992·The American Journal of Physiology·J D LoikeD Stern
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KirinoA Tamura
Sep 24, 1990·Brain Research·K KitagawaK Mikoshiba
May 1, 1983·Journal of Neurochemistry·Y NodaE G McGeer
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J HamadaM Reivich
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S KobayashiF A Welsh
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·C HeurteauxM Lazdunski
Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·K Matsushima, A M Hakim
Aug 1, 1994·Journal of Applied Physiology·S I HarikJ C LaManna
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S S GlazierF A Welsh
May 2, 1994·Brain Research·W Pohle, C Rauca
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M S LawrenceG K Steinberg
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K MatsushimaA M Hakim
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T OhtsukiJ M Hallenbeck
May 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H NawashiroJ M Hallenbeck
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M SakanakaR Sasaki
Aug 13, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T HayashiY Itoyama
Oct 28, 1998·American Journal of Obstetrics and Gynecology·A OtaT Ikenoue
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·H H Marti, W Risau
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J M GiddayT S Park
Apr 17, 1999·Metabolism: Clinical and Experimental·B A BrucknerP W Stacpoole
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M BernaudinE Petit
Jul 17, 1999·Brain Research. Molecular Brain Research·G TomasevicT Wieloch
Jul 21, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N E StaglianoP L Huang
Oct 28, 1999·Brain Research. Developmental Brain Research·T IkedaT Ikenoue
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F WiegandU Dirnagl

❮ Previous
Next ❯

Citations

May 23, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaoqun GaoGuangfu Yin
Feb 3, 2012·Cellular and Molecular Neurobiology·Neetu SinghVikas Mishra
Apr 9, 2013·Translational Stroke Research·Priti Azad, Gabriel G Haddad
Oct 10, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gabor CzibikGuro Valen
Jun 7, 2005·Neurobiology of Disease·Astrid WeberChristoph Bührer
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yanxin Zhao, David A Rempe
May 15, 2003·Trends in Neurosciences·Ulrich DirnaglJohn M Hallenbeck
Dec 2, 2008·Expert Reviews in Molecular Medicine·Constance Tom NoguchiYi Jia
Jan 24, 2009·Nature Reviews. Drug Discovery·Peter FraislPeter Carmeliet
May 21, 2004·Nature Reviews. Neuroscience·Frank R Sharp, Myriam Bernaudin
Sep 10, 2009·Antioxidants & Redox Signaling·Sarah K HartenPatrick H Maxwell
Jan 26, 2010·Antioxidants & Redox Signaling·Orly WeinrebMoussa B H Youdim
Dec 3, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yanli ZhuJeffrey M Gidday
Jan 25, 2005·Journal of Neurochemistry·Christian Bjørn PoulsenJuan Hidalgo
Jun 19, 2008·Molecular and Cellular Biology·Amina A Qutub, Aleksander S Popel
Aug 7, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rena FeinmanDa-Zhong Xu
Jan 1, 2008·PPAR Research·Raghu Vemuganti
Apr 11, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Grace Vangeison, David A Rempe
Oct 13, 2011·BMC Genomics·Huichun XuFrank R Sharp
Feb 22, 2012·Journal of Neuroinflammation·Ann M StoweJeffrey M Gidday
Feb 10, 2010·Experimental & Translational Stroke Medicine·Nadiya Byts, Anna-Leena Sirén
Mar 20, 2010·Experimental & Translational Stroke Medicine·Aysan Durukan, Turgut Tatlisumak
Oct 8, 2004·Critical Care : the Official Journal of the Critical Care Forum·Thomas Coleman, Michael Brines
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Frank R SharpMyriam Bernaudin
Aug 12, 2009·Clinical Ophthalmology·Charanjit KaurEng-Ang Ling
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Ramya KapadiaRaghu Vemuganti
Oct 1, 2014·Pediatric Neurology·Vijayeta Rangarajan, Sandra E Juul
May 18, 2011·Cellular and Molecular Life Sciences : CMLS·Lidia De Filippis, Domenico Delia
Jul 28, 2005·Developmental Neuroscience·Ruiqiong RanFrank R Sharp
Jun 12, 2014·International Journal of Molecular Sciences·Yuanyuan ZhangConstance Tom Noguchi
Jan 1, 2014·Antioxidants·Rachel ShirleyLorraine M Work

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Stroke; a Journal of Cerebral Circulation
Konstantin PrassAndreas Meisel
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
N M Jones, M Bergeron
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Konstantin PrassA Meisel
© 2022 Meta ULC. All rights reserved