Normobaric hypoxia overnight impairs cognitive reaction time

BMC Neuroscience
Stephan PramsohlerNikolaus Cristoph Netzer

Abstract

Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with central apneas and oxygen desaturations, even in perfectly healthy subjects. However, deficits in reaction time in mountaineers or workers after just some nights of hypoxia exposure are not sufficiently explored. Therefore, we aimed to investigate the impact of sleep in a normobaric hypoxic environment on reaction time divided by its cognitive and motoric components. Eleven healthy non acclimatized students (5f, 6m, 21 ± 2.1 years) slept one night at a simulated altitude of 3500 m in a normobaric hypoxic room, followed by a night with polysomnography at simulated 5500 m. Preexisting sleep disorders were excluded via BERLIN questionnaire. All subjects performed a choice reaction test (SCHUHFRIED RT, S3) at 450 m and directly after the nights at simulated 3500 and 5500 m. We found a significant increase of cognitive reaction time with higher altitude (p = 0.026). No changes were detected in movement time (p = n.s.). Reaction time, the combined parameter of cognitive- and motoric reaction time, didn't change either (p = n.s.). Low...Continue Reading

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Citations

Apr 20, 2019·Human Factors·Kristy MartinDavid B Pyne
Sep 25, 2018·Frontiers in Physiology·Matiram PunMarc J Poulin
Aug 14, 2019·International Journal of Environmental Research and Public Health·Hayden D GerhartEllen L Glickman
Nov 28, 2018·Annals of Occupational and Environmental Medicine·Tobias KammererSimon Thomas Schäfer

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